International Journal of Fertility and Menopausal Studies, 38(3), 160-165
To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion.
Random assignment, double-blind.
Community hospitals.
PATIENTS AND
Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed.
Abortion vs. continuation of pregnancy at 16 weeks' gestation.
Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1.
hCG is significantly better than bed rest.
Harrison, R. F. (1993). A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion. *International journal of fertility and menopausal studies*, *38*(3), 160-165.
Harrison RF. A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion. Int J Fertil Menopausal Stud. 1993;38(3):160-165.
Harrison, R. F. "A comparative study of human chorionic gonadotropin, placebo, and bed rest for women with early threatened abortion." *International journal of fertility and menopausal studies*, vol. 38, no. 3, 1993, pp. 160-165.
Abortion, Threatened/drug Therapy/therapy, Adult, Bed Rest, Birth Weight, Chi-Square Distribution, Chorionic Gonadotropin/adverse Effects/therapeutic Use, Double-Blind Method, Female, Humans, Male, Pregnancy, Pregnancy Trimester, First, Progesterone/blood, Sex Ratio, Treatment Outcome, Chorionic Gonadotropin, Progesterone