Clinical Endocrinology, 18(6), 571-592
The physiological requirement for activation of pituitary gonadotrophin secretion by pulsatile LHRH stimulation is discussed, and compared with the effect of pituitary stimulation by LHRH agonists. Initial stimulation is followed by a phase of progressive pituitary and gonadal inhibition. This inhibition is fully reversible at the end of agonist treatment. Clinical applications of high dose suppression are the treatment of precocious puberty and hormone-dependent tumours (mammary and prostatic carcinoma). In women, agonist administration by nasal spray is a reversible method of inhibiting ovulation, and may also be useful in the treatment of endometriosis. Clinical advantages of agonist therapy are favourable biological tolerance, lack of side effects and rapid reversibility.
Sandow, J. (1983). Clinical applications of LHRH and its analogues. *Clinical endocrinology*, *18*(6), 571-592. https://doi.org/10.1111/j.1365-2265.1983.tb00595.x
Sandow J. Clinical applications of LHRH and its analogues. Clin Endocrinol (Oxf). 1983;18(6):571-592. doi:10.1111/j.1365-2265.1983.tb00595.x
Sandow, J. "Clinical applications of LHRH and its analogues." *Clinical endocrinology*, vol. 18, no. 6, 1983, pp. 571-592.
Adolescent, Adult, Animals, Buserelin, Climacteric/drug Effects, Contraception, Corpus Luteum/physiology, Cryptorchidism/drug Therapy, Female, Gonadotropin-Releasing Hormone/analogs & Derivatives/pharmacology/therapeutic Use, Humans, Hypogonadism/drug Therapy, Luteinizing Hormone/metabolism, Male, Ovulation/drug Effects, Pituitary Gland/metabolism, Prostatic Neoplasms/drug Therapy, Puberty, Delayed/drug Therapy, Puberty, Precocious/drug Therapy, Rats, Testis/metabolism, Gonadotropin-Releasing Hormone, Luteinizing Hormone, Buserelin, Age Factors, Amenorrhea, Animals, Laboratory, Biology, Breast Cancer, Cancer, Central Nervous System, Child, Contraception, Contraception Research, Contraceptive Mode Of Action, Corpus Luteum, Demographic Factors, Diseases, Endocrine System, Endometrial Effects, Endometrium, Family Planning, Follicle Stimulating Hormone, Genitalia, Genitalia, Female, Genitalia, Male, Gonadotropins, Hormones, Hypothalamus, Literature Review, Luteinizing Hormone, Male Contraception, Menopause, Menstruation Disorders, Neoplasms, Ovary, Ovulation, Ovulation Suppression, Physiology, Pituitary Gland, Pituitary Hormone Releasing Hormones--administraction and Dosage, Pituitary Hormone Releasing Hormones--therapeutic Use, Population, Population Characteristics, Prostate, Reproduction, Urogenital System, Uterus, Youth