Single-dose administration of an aromatase inhibitor for ovarian stimulation
Infertility > Female Factor > Ovulatory DysfunctionReproductive Endocrinology > Ovulation > Induction
Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat
Fertility and Sterility, 80(6), 1330-1332
Abstract
Objective
To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E2, FSH, LH, and T.
Design
Controlled prospective study.
Setting
University research laboratory.
ANIMAL(S): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age.
INTERVENTION(S): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 microg/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized.
MAIN OUTCOME MEASURE(S): Number of mature follicles, endometrial thickness, and serum levels of hormones.
RESULT(S): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ.
CONCLUSION(S): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate.
Topics
Cite this article
Kilic-Okman, T., Kucuk, M., & Altaner, S. (2003). Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat. *Fertility and sterility*, *80*(6), 1330-1332. https://doi.org/10.1016/j.fertnstert.2003.05.002
Kilic-Okman T, Kucuk M, Altaner S. Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat. Fertil Steril. 2003;80(6):1330-1332. doi:10.1016/j.fertnstert.2003.05.002
Kilic-Okman, Tulay, et al. "Comparison of the effects of letrozole and clomiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat." *Fertility and sterility*, vol. 80, no. 6, 2003, pp. 1330-1332.
Keywords
Animals, Cell Count, Clomiphene/pharmacology, Endometrium/drug Effects/physiology, Estradiol/blood, Female, Fertility Agents, Female/pharmacology, Follicle Stimulating Hormone/blood, Letrozole, Luteinizing Hormone/blood, Nitriles/pharmacology, Ovarian Follicle/cytology/drug Effects/physiology, Rats, Rats, Wistar, Reference Values, Testosterone/blood, Triazoles/pharmacology, Fertility Agents, Female, Nitriles, Triazoles, Clomiphene, Testosterone, Estradiol, Letrozole, Luteinizing Hormone, Follicle Stimulating Hormone,