Abstract
Objective To evaluate the effects of Ringer's lactate instillation, Interceed(TC7) (Johnson and Johnson Medical, Inc., New Brunswick NJ), and Gore-Tex Surgical Membrane (W. L. Gore and Associates, Inc., Flagstaff, AZ) in a rat uterine horn model.
Setting Rats were in a conventional laboratory setting.
Participants Sprague-Dawley white rats, weighing 225 to 250 g.
Interventions The left uterine horn was subjected to a standardized lesion by serosal denudation and devascularization. The rats were randomly assigned into control group, Interceed(TC7) group, Gore-Tex group, and Ringer's lactate group.
Main Outcome Measures Degree of adhesions was evaluated 2 weeks after the initial surgery.
Results Adhesion score after Ringer's lactate instillation was significantly lower than those of control, Interceed(TC7), and Gore-Tex groups. Gore-Tex was associated with less adhesion formation than control. No difference was found in the adhesion formation between the Interceed(TC7) group and the control group.
Conclusion Confirming our previous observations, Ringer's lactate instillation is effective in decreasing adhesion formation. Gore-Tex reduces adhesion formation, but its efficacy is inferior to those of Ringer's lactate. Contrary to previous reports, Interceed(TC7) is ineffective in our animal model.
Ringer's lactate adhesion prevention postsurgical, Interceed TC7 versus Gore-Tex adhesion barrier comparison, postoperative adhesion formation prevention rat model, adhesion barrier materials randomized animal study, Pagidas Tulandi adhesion prevention uterine horn model, oxidized regenerated cellulose PTFE adhesion prevention comparison, Ringer's lactate instillation adhesion reduction surgery, Gore-Tex surgical membrane adhesion prevention efficacy, Interceed ineffective adhesion prevention animal model, surgical adhesion barrier materials effectiveness comparison
PMID 1730317 1730317 DOI 10.1016/s0015-0282(16)54801-8 10.1016/s0015-0282(16)54801-8
Keywords
Animals, Cellulose, Oxidized, Female, Isotonic Solutions, Membranes, Artificial, Polytetrafluoroethylene, Postoperative Complications/prevention & Control, Rats, Rats, Inbred Strains, Ringer's Lactate, Tissue Adhesions/prevention & Control, Uterine Diseases/prevention & Control, Uterus/surgery, Cellulose, Oxidized, INTERCEED, Isotonic Solutions, Membranes, Artificial, Ringer's Lactate, Polytetrafluoroethylene