hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease

Cole LA

hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease

Cole LA, 1998

The Journal of Reproductive Medicine, 43(1), 3-10

Source

Abstract

Objective

To examine the structure and metabolism of human chorionic gonadotropin (hCG) and the effect of molecular heterogeneity on the immunodiagnosis and monitoring of gestational trophoblastic disease.

Study Design

A review of the current medical literature concerning measurement of hCG and hCG-related molecules.

Results

hCG molecules in gestational trophoblastic disease are more heterogeneous or degraded in serum and urine samples than in normal pregnancy.

Conclusion

Appropriate measurement and monitoring of hCG levels in gestational trophoblastic disease require an understanding of hCG structure and metabolism.

Topics

Pregnancy > Biochemistry > hCG Structure and Metabolism Diagnostics > Biomarkers > hCG Measurement in Trophoblastic Disease General OB/GYN > Gynecologic Oncology > Gestational Trophoblastic Disease

hCG free subunits metabolism gestational trophoblastic disease, human chorionic gonadotropin molecular heterogeneity immunodiagnosis, Cole LA hCG structure metabolism review, hCG measurement trophoblastic disease monitoring, hCG beta subunit degradation serum urine pregnancy, gestational trophoblastic disease hCG level monitoring, hCG related molecules normal pregnancy vs trophoblastic disease, immunoassay hCG molecular variants clinical significance, hCG metabolites urine pregnancy diagnosis, human chorionic gonadotropin heterogeneity assay interference

Cite this article

Cole, L. A. (1998). hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease. *The Journal of reproductive medicine*, *43*(1), 3-10.

Keywords

Biomarkers/blood/urine, Chorionic Gonadotropin/analysis/chemistry/metabolism/physiology, Circadian Rhythm, Epitopes/immunology, Female, Humans, Pregnancy/blood/physiology/urine, Reagent Kits, Diagnostic, Reproducibility of Results, Trophoblastic Neoplasms/blood/urine, Uterine Neoplasms/blood/urine, Biomarkers, Chorionic Gonadotropin, Epitopes, Reagent Kits, Diagnostic

hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease

Abstract

Topics

Cite this article

Keywords

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