Gynecologic and Obstetric Investigation, 33(3), 183-184
Some randomized studies have suggested a significant beneficial effect of 17-hydroxyprogesterone caproate in the prevention of preterm labor [1, 2], The therapy in both studies was initiated at approximately 12-16 weeks and continued until labor.
We considered the possibility that a deficient proges terone effect during the first trimester may lead to a higher rate of preterm deliveries. A retrospective study was thus performed comparing the incidence of preterm versus full-term pregnancies in women with luteal phase defects who were either treated or not treated with proges terone supplementation during the first trimester.
Check, J. H., Lee, G., Epstein, R., & Vetter, B. (1992). Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report. *Gynecologic and obstetric investigation*, *33*(3), 183-184. https://doi.org/10.1159/000294877
Check JH, Lee G, Epstein R, Vetter B. Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report. Gynecol Obstet Invest. 1992;33(3):183-184. doi:10.1159/000294877
Check, J. H., et al. "Increased rate of preterm deliveries in untreated women with luteal phase deficiencies. Preliminary report." *Gynecologic and obstetric investigation*, vol. 33, no. 3, 1992, pp. 183-184.
Analysis of Variance, Birth Weight, Female, Humans, Infant, Newborn, Luteal Phase, Obstetric Labor, Premature/etiology/prevention & Control, Pregnancy, Pregnancy Trimester, First, Progesterone/administration & Dosage/blood/therapeutic Use, Retrospective Studies, Surveys and Questionnaires, Time Factors, Progesterone,