British Journal of Obstetrics and Gynaecology, 104(4), 499-502
Interleukin-8 (IL-8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL-8 was detected in the urine of 91 of 104 women with premature rupture of the fetal membranes, with values exceeding 1000 ng/L in cases of severe intra-amniotic infection. Women with urinary tract infections were excluded. The routine measurement of IL-8 in urine, together with C-reactive protein in serum, thus provides a low risk and technically simple approach to the assessment of intra-amniotic infection.
Stiemer, B., Buschmann, A., Bisson, S., Hensel, K., Gramm, H. J., Hopp, H., & Weitzel, H. K. (1997). Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes. *British journal of obstetrics and gynaecology*, *104*(4), 499-502. https://doi.org/10.1111/j.1471-0528.1997.tb11504.x
Stiemer B, Buschmann A, Bisson S, Hensel K, Gramm HJ, Hopp H, et al. Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes. Br J Obstet Gynaecol. 1997;104(4):499-502. doi:10.1111/j.1471-0528.1997.tb11504.x
Stiemer, B., et al. "Interleukin-8 in urine: a new diagnostic parameter for intra-amniotic infection after premature rupture of the membranes." *British journal of obstetrics and gynaecology*, vol. 104, no. 4, 1997, pp. 499-502.
Amnion, Enzyme-Linked Immunosorbent Assay, Female, Fetal Membranes, Premature Rupture/urine, Humans, Interleukin-8/urine, Pregnancy, Pregnancy Complications, Infectious/diagnosis, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prenatal Diagnosis/methods, Sensitivity and Specificity, Interleukin-8