0 My Account

Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation

Barrett CT et al., 1974

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 48(34), 1456-1458

Source

Abstract

Summary

The use of clomiphene in gradually increasing doses, in cases of infertility due to anovulation, oligo-ovulation and inadequate luteal phase, led to a high pregnancy rate, particularly in the initial stages of treatment. Although clomiphene is a relatively safe and inexpensive drug, there is a possibility that high doses in repeated cycles may adversely affect fertility by its anti-oestrogenic effect. It is therefore suggested that therapy be commenced with a lower dosage than that generally recommended.

Topics

Infertility > Medical Treatment > Clomiphene CitrateInfertility > Ovulation Induction > Dose OptimizationReproductive Endocrinology > Ovulatory Dysfunction > Anovulation Treatment
low dose clomiphene infertility anovulation treatment, clomiphene citrate inadequate luteal phase therapy, clomiphene dose escalation ovulation induction, anti-estrogenic effect clomiphene high dose fertility, Barrett Hakim clomiphene low dosage infertility, oligo-ovulation clomiphene treatment pregnancy rate, clomiphene starting dose recommendation infertility, anovulatory infertility oral ovulation induction agents, clomiphene repeated cycles adverse fertility effects, defective ovulation clomiphene graduated dosing protocol

Cite this article

Barrett, C. T., & Hakim, C. A. (1974). Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation. *South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde*, *48*(34), 1456-1458.

Keywords

Abortion, Spontaneous/epidemiology, Adult, Amenorrhea/drug Therapy, Body Temperature, Clomiphene/administration & Dosage/pharmacology/therapeutic Use, Female, Humans, Infertility, Female/drug Therapy/physiopathology, Ovulation/drug Effects, Pregnancy, Pregnancy, Ectopic/epidemiology, Pregnancy, Multiple, Twins, Clomiphene

Related articles

Oral clomiphene citrate and vaginal progesterone suppositories in the treatment of luteal phase dysfunction: a comparative study
Murray DL et al., 1989 Fertility and Sterility

Oral clomiphene citrate (CC) and vaginal progesterone suppositories (PS) are common treatment modalities in luteal phase dysfunction (LPD). Little is known regarding the relative efficacy of these age...

Infertility > Luteal Phase Defect > Treatment ComparisonInfertility > Medical Treatment > Clomiphene CitrateInfertility > Medical Treatment > Progesterone Supplementation

C-reactive protein as a predictor of fetal and maternal infective morbidity and fetal mortality
de Souza JJ et al., 1987 South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde

The value of maternal C-reactive protein (CRP) levels as predictors of fetal and maternal infective morbidity and fetal mortality was assessed prospectively over a 6-month period in all cases of prema...

Pregnancy > Complications > Premature Rupture of MembranesPregnancy > Maternal Infection > Inflammatory BiomarkersDiagnostics > Biomarkers > C-Reactive Protein in Pregnancy