Low Dose Naltrexone: Novel Uses for a Licensed Medication

Naltrexone hydrochloride is a licensed drug with a growing number of novel uses. Nothing has been published on low dose naltrexone for infertility, miscarriage, PMS, or pregnancy, but there is published literature on high dose naltrexone. First synthesised in the 1960s and licensed in the USA in 1985 and Ireland in 1991, naltrexone at 50-150mg per dose is used as adjunctive treatment of opioid dependence and now alcohol dependence (unlicensed). It works through competitive inhibition of opioid receptors in both the central and peripheral nervous system.