Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects

Stanford JB, Mikolajczyk RT

doi:10.1067/mob.2002.128091

Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects

Stanford JB et al., 2002

American Journal of Obstetrics and Gynecology, 187(6), 1699-1708

DOI 10.1067/mob.2002.128091 PMID 12501086

Abstract

There are many potential mechanisms of action for the intrauterine device (IUD), which vary by type of IUD (inert, copper, or hormonal). This paper reviews the evidence for each potential mechanism of action. On the basis of available data for fertilization rates and clinical pregnancy rates, the relative contribution of mechanisms acting before or after fertilization were quantitatively estimated. These estimates indicate that, although prefertilization effects are more prominent for the copper IUD, both prefertilization and postfertilization mechanisms of action contribute significantly to the effectiveness of all types of intrauterine devices.

Topics

Contraception/Comparison > Intrauterine Devices > Mechanisms of Action Contraception/Comparison > Intrauterine Devices > Postfertilization Effects Ethics/Philosophy > Contraception Ethics > Abortifacient Mechanisms

intrauterine device mechanism of action postfertilization effects, IUD prefertilization vs postfertilization mechanisms, copper IUD mechanism fertilization prevention, hormonal IUD implantation prevention mechanism, Stanford Mikolajczyk IUD mechanisms of action, inert copper hormonal IUD effectiveness comparison, IUD postfertilization effect quantitative estimation, intrauterine device clinical pregnancy rate fertilization rate, ethical concerns IUD abortifacient mechanism, contraceptive mechanism pre-implantation embryo loss

PMID 12501086 12501086 DOI 10.1067/mob.2002.128091 10.1067/mob.2002.128091

Cite this article

Stanford, J. B., & Mikolajczyk, R. T. (2002). Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects. *American journal of obstetrics and gynecology*, *187*(6), 1699-1708. https://doi.org/10.1067/mob.2002.128091

Keywords

Cervix Mucus, Endometrium/physiology, Fallopian Tubes/cytology, Female, Fertilization, Humans, Intrauterine Devices, Intrauterine Devices, Copper, Intrauterine Devices, Medicated, Levonorgestrel, MEDLINE, Oocytes, Pregnancy, Pregnancy, Ectopic, Sperm Transport, Levonorgestrel

Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects

Abstract

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Cite this article

Keywords

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