Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium

Ferre F, Uzan M, Janssens Y, Tanguy G, Jolivet A, Breuiller M, Sureau C, Cedard L

doi:10.1016/s0002-9378(84)80027-7

Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium

Ferre F et al., 1984

American Journal of Obstetrics and Gynecology, 148(1), 26-34

DOI 10.1016/s0002-9378(84)80027-7 PMID 6691378

Abstract

A single dose of micronized oral progesterone was administered to 15 pregnant women immediately prior to elective cesarean section. Levels of progesterone, 17 beta-estradiol, and estrone were measured in the plasma, in the placenta, and at different sites in myometrium obtained during the surgical procedure. Results were compared to those observed in a control group of women who did not receive progesterone. Progesterone levels demonstrated a marked increase in plasma and in the whole myometrium 150 minutes after administration. The levels then decreased rapidly to control values in 1 hour. The concentrations of progesterone in the placenta did not show any changes. No difference appeared in 17 beta-estradiol levels in the plasma or the myometrium, whereas an increase was observed in the placenta. Estrone levels did not change in the plasma, but they decreased in the myometrium and in the placenta.

Topics

Reproductive Endocrinology > Progesterone > Oral Micronized Pharmacokinetics Pregnancy > Hormonal Physiology > Progesterone Tissue Distribution Reproductive Endocrinology > Progesterone > Myometrial Concentration

oral micronized progesterone late pregnancy pharmacokinetics, micronized progesterone plasma myometrium concentration cesarean section, oral progesterone absorption myometrial tissue distribution pregnancy, Ferre micronized progesterone pregnancy placenta myometrium, progesterone estradiol estrone levels myometrium oral administration, oral progesterone bioavailability uterine tissue pregnancy, micronized progesterone pharmacokinetics pregnant women, progesterone concentration placenta myometrium after oral dose, natural progesterone administration estrogen levels pregnancy tissue, oral micronized progesterone myometrial uptake clearance rate

PMID 6691378 6691378 DOI 10.1016/s0002-9378(84)80027-7 10.1016/s0002-9378(84)80027-7

Cite this article

Ferre, F., Uzan, M., Janssens, Y., Tanguy, G., Jolivet, A., Breuiller, M., Sureau, C., & Cedard, L. (1984). Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. *American journal of obstetrics and gynecology*, *148*(1), 26-34. https://doi.org/10.1016/s0002-9378(84)80027-7

Keywords

Administration, Oral, Cesarean Section, Estradiol/metabolism, Estrogens/metabolism, Estrone/metabolism, Female, Humans, Myometrium/metabolism, Obstetric Labor, Premature/prevention & Control, Placenta/metabolism, Pregnancy, Progesterone/administration & Dosage/metabolism, Estrogens, Estrone, Progesterone, Estradiol

Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium

Abstract

Topics

Cite this article

Keywords

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