Data from the Oxford.FPA prospective study show that oral contraceptive use and pregnancy have no discernible effect on the risk of developing multiple sclerosis (MS). Women of parity 0-2 developed MS twice as often as women of parity 3 or more but the difference did not reach statistical significance. Smoking may be a risk factor for developing MS. A nested case-control analysis did not identify any associations between MS onset and preceding illnesses.
Villard-Mackintosh L, & Vessey, M. (1993). Oral contraceptives and reproductive factors in multiple sclerosis incidence. *Contraception*, *47*(2), 161-168. https://doi.org/10.1016/0010-7824(93)90088-o
Villard-Mackintosh L, Vessey M. Oral contraceptives and reproductive factors in multiple sclerosis incidence. Contraception. 1993;47(2):161-168. doi:10.1016/0010-7824(93)90088-o
Villard-Mackintosh L, and Martin Vessey. "Oral contraceptives and reproductive factors in multiple sclerosis incidence." *Contraception*, vol. 47, no. 2, 1993, pp. 161-168.
Background: Little is known on fracture risk in young women using oral contraceptives.
Study Design: Case-control study (64,548 cases, 193,641 controls).
Results: Overall, no major association with ri...
Contraception/Comparison > Side Effects > Hormonal ContraceptionBone Health > Menstrual Cycle Effects > Ovulatory DisturbancesGeneral OB/GYN > Epidemiology > Prevalence
Purpose: Combination therapy with the female hormones estrogen (E) and progestins are very frequently used with approximately 100 million women worldwide taking oral contraceptives (OC). Recent trials...
Thorogood M et al., 1999British Journal of Obstetrics and Gynaecology
Objective: To examine the risk of multiple sclerosis in users of combined oral contraceptives.
Design: Cohort study conducted between 1968 and 1996 using diagnostic data supplied by general practition...
Yonis H et al., 2025
Open Access
BMJ (Clinical Research Ed.)
Objective: To evaluate the association between contemporary hormonal contraceptive use and the risk of incident ischaemic stroke and myocardial infarction.
Design: Real-world, nationwide, prospective ...
Contraception/Comparison > Side Effects > Hormonal ContraceptionContraception/Comparison > FABM vs Hormonal > Side EffectsGeneral OB/GYN > Epidemiology > Prevalence