Role of Oral Contraceptive (OC) as a risk factor for cervical cancer remained controversial and unclear.
Objective
To evaluate risk of cervical cancer in OC users and non-users through a comprehensive systematic review. Search Strategy: Literature search conducted in databases from January 1990 till August 2019 using various search terms. Selection Criteria: Primary research studies that evaluated and assessed the association of OC use with cervical cancer with study design of case control or cohort types published in English language. Data Collection and Analysis: PRISMA guided review was done by two independent researchers. Effect size estimated by pooled Odds ratio with 95 % Confidence Interval (CI) in random effect models on OC pill use for the risk of cervical cancer.
Results
Review included 19 studies. Overall risk of invasive cancer on OC use was found to be significant with unknown status of HPV OR (95 % CI) as 1.51 (1.35, 1.68) and for unknown HPV as 1.66 (1.24, 2.21). Adenocarcinoma, squamous cell carcinoma and carcinoma in situ had significant association with OR (95 % CI) of 1.77 (1.4, 2.24), 1.29 (1.18, 1.42) and 1.7 (1.18, 2.44) respectively.
Conclusion
OC pills use had a definite associated risk for developing cervical cancer specially for Adenocarcinoma and longer duration of OC pills use.
oral contraceptives cervical cancer risk, birth control pill cervical cancer, contraceptive use cervical carcinoma, oc pill cervical cancer meta-analysis, hormonal contraception hpv cervical cancer, adenocarcinoma cervical oral contraceptives, squamous cell carcinoma oral contraceptives, birth control duration cancer risk, contraceptive side effects cervical cancer, oral contraceptive long-term risks, cervical cancer hormonal contraception
Cite this article
Asthana, S., Busa, V., & Labani, S. (2020). Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis. *European journal of obstetrics, gynecology, and reproductive biology*, *247*, 163-175. https://doi.org/10.1016/j.ejogrb.2020.02.014
Asthana S, Busa V, Labani S. Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020;247:163-175. doi:10.1016/j.ejogrb.2020.02.014
Asthana, Smita, et al. "Oral contraceptives use and risk of cervical cancer-A systematic review & meta-analysis." *European journal of obstetrics, gynecology, and reproductive biology*, vol. 247, 2020, pp. 163-175.
International Collaboration of Epidemiological Studies of Cervical Cancer et al., 2007Lancet (London, England)
Background: Combined oral contraceptives are classified by the International Agency for Research on Cancer as a cause of cervical cancer. As the incidence of cervical cancer increases with age, the pu...
McFarlane-Anderson N et al., 2008
Open Access
BMC Womens Health
Background: This study was conducted to determine whether use of hormonal contraceptives is associated with cervical dysplasia and cancer in a population where there is widespread use of hormonal cont...
Segarra I et al., 2023
Open Access
Frontiers in Medicine
Hormone-based contraception disrupts hormonal balance, creating artificial states of anovulation and threatening women's health. We reviewed its main adverse effects and mechanisms on accelerated ovar...
Larsen SV et al., 2023
Open Access
JAMA Psychiatry
Importance: Hormonal sensitivity may contribute to the risk of depression in some women, as observed during the premenstrual, postpartum, and perimenopausal phases, and when initiating hormonal contra...