Acta Obstetricia Et Gynecologica Scandinavica, 55(4), 371-375
Of 159 pregnancies conceived after clomiphene therapy, 141 ended in childbirth, including seven sets of twins. There was a probable increase in the number of infants born with major malformations. These were exclusively to women who had not previously borne a normal infant. The incidence of malformed infants compares well with that published after gonadotropin therapy. The possibly higher incidence of malformations seen after drug-induced ovulation would therefore seem to be due to the underlying subfertility state and thus not a direct drug effect.
Ahlgren, M., Källén, B., & Rannevik, G. (1976). Outcome of pregnancy after clomiphene therapy. *Acta obstetricia et gynecologica Scandinavica*, *55*(4), 371-375. https://doi.org/10.3109/00016347609158516
Ahlgren M, Källén B, Rannevik G. Outcome of pregnancy after clomiphene therapy. Acta Obstet Gynecol Scand. 1976;55(4):371-375. doi:10.3109/00016347609158516
Ahlgren, Mats, et al. "Outcome of pregnancy after clomiphene therapy." *Acta obstetricia et gynecologica Scandinavica*, vol. 55, no. 4, 1976, pp. 371-375.
Abnormalities, Drug-Induced, Anovulation/drug Therapy, Clomiphene/adverse Effects/therapeutic Use, Female, Humans, Pregnancy, Pregnancy Complications/chemically Induced, Pregnancy, Multiple, Teratogens, Twins, Teratogens, Clomiphene, Abortion, Spontaneous, Clomiphene--administraction and Dosage, Clomiphene--side Effects, Clomiphene--therapeutic Use, Congenital Abnormalities, Diseases, Family Planning, Fertility Agents, Gonadotropins, Gonadotropins, Chorionic, Incidence, Maternal Age, Measurement, Neonatal Diseases And Abnormalities, Pregnancy, Multiple, Reproductive Control Agents, Research Methodology