JAMA, 220(10), 1329-1333
Eighty-six women reached at least 20 weeks' pregnancy in 96 instances, after ovulation induced by clomiphene citrate. Although 37 of the women had 44 previous pregnancies, there had been a high pregnancy wastage (70.5%) producing only 13 live infants prior to the successful clomiphene therapy. After clomiphene therapy, pregnancies were normal except for a high incidence of toxemia (16.7%) and a possibly increased incidence of prediabetes. The pregnancies resulted in 88 single and 8 twin births. The total fetal and neonatal loss was 6.7%. The loss of single births (3.1%) included two stillbirth infants of prediabetic mothers. The twin loss of 25% was due to prematurity. The incidence of congenital malformations was within normal limits.
Hack, M., Brish, M., Serr, D. M., Insler, V., Salomy, M., & Lunenfeld, B. (1972). Outcome of pregnancy after induced ovulation. Follow-up of pregnancies and children born after clomiphene therapy. *JAMA*, *220*(10), 1329-1333.
Hack M, Brish M, Serr DM, Insler V, Salomy M, Lunenfeld B. Outcome of pregnancy after induced ovulation. Follow-up of pregnancies and children born after clomiphene therapy. JAMA. 1972;220(10):1329-1333.
Hack, M., et al. "Outcome of pregnancy after induced ovulation. Follow-up of pregnancies and children born after clomiphene therapy." *JAMA*, vol. 220, no. 10, 1972, pp. 1329-1333.
Adult, Cesarean Section, Citrates/pharmacology, Clomiphene/administration & Dosage/pharmacology/therapeutic Use, Drug Synergism, Female, Fetal Death, Follow-Up Studies, Gestational Age, Humans, Infant Mortality, Infant, Newborn, Infertility, Female/drug Therapy, Male, Ovulation/drug Effects, Parity, Pre-Eclampsia, Prediabetic State, Prednisone/administration & Dosage, Pregnancy, Sex Ratio, Time Factors, Twins, Citrates, Clomiphene, Prednisone,