Pharmacokinetics of progesterone administered by the oral and parenteral routes

The Journal of Reproductive Medicine, 44(2 Suppl), 141-147

Source

Abstract

Progestogens, which include the natural hormone, progesterone, and synthetic steroid derivatives, are used to treat a variety of reproductive disorders. Since synthetic progestogens are often associated with undesirable side effects, improved formulations and modes of administration of progesterone have been sought. In order to find an optimal therapeutic agent, different progesterone formulations and routes of administration have been studied. This paper explains several methods of measuring progesterone levels and summarizes clinical data on the pharmacokinetic profiles of natural progesterone administered by the oral, intramuscular, vaginal, intranasal, percutaneous, sublingual and rectal routes.

Topics

progesterone pharmacokinetics oral vaginal intramuscular administration, natural progesterone formulations routes of administration, progesterone bioavailability oral vs vaginal vs sublingual, Stanczyk progesterone pharmacokinetics review, progesterone measurement methods serum levels, synthetic progestogens vs natural progesterone side effects, percutaneous intranasal rectal progesterone delivery, progesterone formulation reproductive disorders treatment, natural progesterone absorption routes clinical comparison, progesterone levels measurement oral parenteral routes

Cite this article

Stanczyk, F. Z. (1999). Pharmacokinetics of progesterone administered by the oral and parenteral routes. *The Journal of reproductive medicine*, *44*(2 Suppl), 141-147.

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