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Physiologic effects of lowering caloric intake in nonhuman primates and nonobese humans

S B Roberts et al., 2001

J Gerontol A Biol Sci Med Sci, 56 Spec No 1(Supplement 1), 66-75

DOI 10.1093/gerona/56.suppl_1.66 PMID 12088214 Source

Abstract

Caloric restriction (CR) reduces the rate of aging and increases life span in all small animal species studied to date, but the effects of CR in humans remain uncertain. This review summarizes current knowledge of the effects of CR in nonhuman primates and humans. The results suggest that CR has a range of beneficial effects in nonhuman primates studied under laboratory conditions, and short-term markers of CR seen in animal models appear to occur in humans subject to CR also. However, the overall benefit of CR in human populations remains to be established, and studies in human populations are needed.

Topics

Perimenopause/Menopause > Metabolism > Caloric RestrictionResearch Methodology > Review Articles > Translational ResearchGeneral OB/GYN > Nutrition > Energy Balance
caloric restriction aging nonhuman primates humans, low calorie intake physiologic effects longevity, Prior JC caloric restriction reproductive effects, caloric restriction life span extension human applicability, energy restriction nonobese humans biomarkers aging, caloric restriction primate studies metabolic effects, dietary restriction aging markers human populations, Ellison caloric restriction reproductive physiology, Roberts Pi-Sunyer caloric restriction review, CR biomarkers animal models human translation
PMID 12088214 12088214 DOI 10.1093/gerona/56.suppl_1.66 10.1093/gerona/56.suppl_1.66

Cite this article

S B Roberts, X Pi-Sunyer, L Kuller, M A Lane, P Ellison, J C Prior, & S Shapses (2001). Physiologic effects of lowering caloric intake in nonhuman primates and nonobese humans. *The journals of gerontology. Series A, Biological sciences and medical sciences*, *56 Spec No 1*(Supplement 1), 66-75. https://doi.org/10.1093/gerona/56.suppl_1.66