Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Andrew FD, Staples RE

doi:10.1002/tera.1420150104

Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Andrew FD et al., 1977

Teratology, 15(1), 25-32

DOI 10.1002/tera.1420150104 PMID 841480

Abstract

Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.

Topics

Reproductive Endocrinology > Progestogens > Teratogenicity Pregnancy > Prenatal Exposures > Synthetic Hormones Research Methodology > Animal Models > Teratology Studies

medroxyprogesterone acetate prenatal toxicity animal study, MPA teratogenicity rabbits rats mice, medroxyprogesterone cleft palate birth defects, progestogen prenatal exposure fetal malformations, medroxyprogesterone acetate gestational toxicology, synthetic progestin teratology animal model, MPA dose-response cleft palate rabbits, prenatal progestogen safety fetal development, medroxyprogesterone subcutaneous injection gestation, New Zealand Dutch Belted rabbit teratology progestin

PMID 841480 841480 DOI 10.1002/tera.1420150104 10.1002/tera.1420150104

Cite this article

Andrew, F. D., & Staples, R. E. (1977). Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice. *Teratology*, *15*(1), 25-32. https://doi.org/10.1002/tera.1420150104

Keywords

Abnormalities, Drug-Induced, Animals, Body Weight/drug Effects, Cleft Palate/chemically Induced, Dose-Response Relationship, Drug, Female, Fetal Death, Gestational Age, Maternal-Fetal Exchange, Medroxyprogesterone/toxicity, Mice, Pregnancy, Rabbits, Rats, Medroxyprogesterone

Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice

Abstract

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Cite this article

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