Prevention of postoperative tubal adhesions. Comparative study of commonly used agents

Hodger GD, diZerega GS

doi:10.1016/0002-9378(80)90591-8

Prevention of postoperative tubal adhesions. Comparative study of commonly used agents

Hodger GD et al., 1980

American Journal of Obstetrics and Gynecology, 136(2), 173-178

DOI 10.1016/0002-9378(80)90591-8 PMID 6766273

Abstract

Tubal abrasions were surgically induced in 25 rhesus monkeys following demonstration of tubal patency. Five monkeys received dexamethasone, promethazine, and ampicillin perioperatively, five received intraperitoneal 10% dextran 40, five received intraperitoneal 32% dextran 70, and 10 received no additional therapy. Fimbrial biopsies were obtained from two additional monkeys treated with 32% dextran 70 before and postoperatively on days 2, 5, and 7. Only those treated with 32% dextran 70 retained tubal patency and avoided development of adhesions, involving fimbria, omentum, ovary, uterus, and bladder. Histologic examination of fimbrial biopsies demonstrated sufficient epithelial repair to have occurred during the 5 days 32% dextran 70 remained in the pelvin cavity to prevent adhesion formation.

Topics

Surgery > Adhesion Prevention > Tubal Surgery Surgery > Reproductive Surgery > Fallopian Tube Patency Infertility > Tubal Factor > Postoperative Adhesion Prevention

postoperative tubal adhesion prevention dextran 70, tubal adhesion prevention comparative study rhesus monkey, dextran 70 intraperitoneal adhesion prevention tubal surgery, diZerega tubal adhesion prevention dexamethasone dextran, fimbrial adhesion prevention reproductive surgery primate model, dexamethasone promethazine ampicillin adhesion prevention ineffective, tubal patency preservation postoperative adhesion prevention, fimbrial epithelial repair adhesion barrier mechanism, surgical adhesion prevention fallopian tube fertility, intraperitoneal dextran tubal surgery adhesion formation

PMID 6766273 6766273 DOI 10.1016/0002-9378(80)90591-8 10.1016/0002-9378(80)90591-8

Cite this article

DiZerega, G. S., & Hodger, G. D. (1980). Prevention of postoperative tubal adhesions. Comparative study of commonly used agents. *American journal of obstetrics and gynecology*, *136*(2), 173-178. https://doi.org/10.1016/0002-9378(80)90591-8

Keywords

Ampicillin/therapeutic Use, Animals, Biopsy, Dexamethasone/therapeutic Use, Dextrans/therapeutic Use, Fallopian Tube Diseases/pathology/prevention & Control, Fallopian Tube Patency Tests, Female, Haplorhini, Macaca Mulatta, Postoperative Complications/prevention & Control, Promethazine/therapeutic Use, Tissue Adhesions, Dextrans, Ampicillin, Dexamethasone, Promethazine, Adhesions, Animals, Laboratory, Clinical Research, Comparative Studies, Diseases, Female Sterilization, Gynecologic Surgery, Postoperative Procedures, Research Methodology, Signs And Symptoms, Studies, Surgery, Treatment

Prevention of postoperative tubal adhesions. Comparative study of commonly used agents

Abstract

Topics

Cite this article

Keywords

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