Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Michaelis J, Michaelis H, Glück E, Koller S

doi:10.1002/tera.1420270109

Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Michaelis J et al., 1983

Teratology, 27(1), 57-64

DOI 10.1002/tera.1420270109 PMID 6845218

Abstract

From 1964 to 1976, a cohort study was performed in West Germany to study the possible influence of various factors on pregnancy and child development. Results of the evaluation of 13,643 pregnancies are given with respect to possible teratogenetic effects of antiemetic drugs and sex hormones administered in early pregnancy. There was no evidence of an increased risk of major malformations following the intake of certain antiemetic drugs and progesterone. Also, the use of a hormonal pregnancy test was not significantly associated with an increase of major malformations.

Topics

Pregnancy > Drug Safety > Progesterone Exposure Pregnancy > Teratology > Hormonal Agents Research Methodology > Epidemiology > Prospective Cohort Studies

progesterone early pregnancy congenital malformations safety, sex hormones pregnancy teratogenicity prospective cohort, antiemetic drugs pregnancy birth defects, hormonal pregnancy test congenital malformation risk, Michaelis prospective cohort drug exposure pregnancy, progesterone supplementation first trimester safety, teratogenic risk drugs early pregnancy large cohort, progestogen exposure pregnancy fetal malformation, drug safety pregnancy prospective epidemiologic study, congenital malformations hormone exposure cohort West Germany

PMID 6845218 6845218 DOI 10.1002/tera.1420270109 10.1002/tera.1420270109

Cite this article

Michaelis, J., Michaelis, H., Glück, E., & Koller, S. (1983). Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations. *Teratology*, *27*(1), 57-64. https://doi.org/10.1002/tera.1420270109

Keywords

Abnormalities, Drug-Induced/epidemiology, Antiemetics/adverse Effects, Dicyclomine, Doxylamine/adverse Effects, Drug Combinations/adverse Effects, Estradiol/adverse Effects/analogs & Derivatives, Female, Germany, West, Humans, Pregnancy, Progesterone/adverse Effects, Prospective Studies, Pyridoxine/adverse Effects, Time Factors, Antiemetics, Drug Combinations, Dicyclomine, Doxylamine, Pyridoxine Drug Combination, Progesterone, Dicyclomine, Estradiol, Estradiol Benzoate, Progesterone Drug Combination, Doxylamine, Pyridoxine

Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Abstract

Topics

Cite this article

Keywords

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