Cancer Causes & Control : CCC, 18(2), 189-198, 2007
Risk of breast cancer associated with short-term use of oral contraceptives
Suzanne G. Folger , Jill A McDonald, Leslie Bernstein
Giske Ursin, Jesse A Berlin, Brian L Strom, Michael S Simon, Kathleen E Malone, Ronald T Burkman , Janet R Daling , Polly A Marchbanks , Sandra A Norman , Robert Spirtas , Linda Weiss
Author affiliations (14)
National Center for Chronic Disease Prevention and Health PromotionROR
Division of Cancer Etiology, Department of Population Sciences, City of Hope Medical Center, Duarte, California; Departments of 2Preventive Medicine and 3Pathology, Keck School of Medicine, Univers...ROR
Division of Cancer Etiology, Department of Population Sciences, City of Hope Medical Center, Duarte, California; Departments of 2Preventive Medicine and 3Pathology, Keck School of Medicine, Univers...
To estimate breast cancer risk associated with short-term (<6 months) oral contraceptive use, and explore variation in estimates by use characteristics and medical, menstrual, and reproductive history.
Methods
We analyzed data from the Women's Contraceptive and Reproductive Experiences Study. Case subjects were white women and black women, 35-64 years old, diagnosed with invasive breast cancer in July 1994-April 1998. Control subjects identified by random-digit dialing were matched to case subjects by age, race, and study site. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Overall, short-term oral contraceptive use was not associated with breast cancer risk (OR = 1.0; 95% CI = 0.8-1.1). However, significant interaction between short-term use and menopausal status led to an observed increased breast cancer risk in pre-menopausal women (OR = 1.3; 95% CI = 1.0-1.7) and a reduced risk in post-menopausal women (OR = 0.8; 95% CI = 0.6-1.0) associated with short-term use. The association was more pronounced in women with non-contraceptive reasons for use and underlying risk factors for breast cancer.
Conclusions
These associations may result from underlying characteristics of users or unmeasured factors influencing duration of use and breast cancer risk.
short-term oral contraceptive use breast cancer risk, oral contraceptive duration breast cancer premenopausal women, hormonal contraception breast cancer case-control study, menopausal status oral contraceptive breast cancer interaction, Women's Contraceptive Reproductive Experiences Study breast cancer, oral contraceptive non-contraceptive use breast cancer risk, short duration pill use breast cancer odds ratio, premenopausal breast cancer risk oral contraceptive exposure, Folger Marchbanks oral contraceptive breast cancer, racial differences oral contraceptive breast cancer risk
PMID 17216547 17216547 DOI 10.1007/s10552-006-0086-7 10.1007/s10552-006-0086-7
Cite this article
Folger, S. G., Marchbanks, P. A., McDonald, J. A., Bernstein, L., Ursin, G., Berlin, J. A., Daling, J. R., Norman, S. A., Strom, B. L., Weiss, L. K., Simon, M. S., Burkman, R. T., Malone, K. E., & Spirtas, R. (2007). Risk of breast cancer associated with short-term use of oral contraceptives. Cancer causes & control : CCC, 18(2), 189-198. https://doi.org/10.1007/s10552-006-0086-7
Folger SG, Marchbanks PA, McDonald JA, Bernstein L, Ursin G, Berlin JA, et al. Risk of breast cancer associated with short-term use of oral contraceptives. Cancer Causes Control. 2007;18(2):189-198. doi:10.1007/s10552-006-0086-7
Folger, S. G., et al. "Risk of breast cancer associated with short-term use of oral contraceptives." Cancer causes & control : CCC, vol. 18, no. 2, 2007, pp. 189-198.
Keywords
Contraceptives, Oral
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