Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Harrison RF, Youssefnejadian E, Brodovcky H, Johnson M, Dewhurst J

doi:10.1111/j.1471-0528.1978.tb15855.x

Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Harrison RF et al., 1978

British Journal of Obstetrics and Gynaecology, 85(12), 927-932

DOI 10.1111/j.1471-0528.1978.tb15855.x PMID 737159

Abstract

Plasma progesterone, 17-hydroxyprogesterone, 20alpha hydroxypregn-4-en-3-one levels were determined twice weekly up to 16 weeks gestation, where possible, in a twin pregnancy, in two patients who aborted spontaneously and in three patients who were treated with 'progesterone supplements' because of abnormal vaginal cytology. There was no correlation between vaginal smears and the plasms hormone levels and there was no evidence to suggest that progesterone supplements influenced clinical outcome. Compared with normal mean values the only difference was a significantly rise in progesterone and 20alpha hydroxypregn-4-en-3-one levels in the twin pregnancy after the 12th week and a precipitate fall in all hormone levels just prior to abortion. Plasma hormone levels could not be used to predict outcome.

Topics

Pregnancy > Early Pregnancy > Hormone Monitoring Pregnancy > Complications > Spontaneous Abortion Diagnostics > Hormone Assessment > Progesterone Levels in Pregnancy

plasma progesterone levels early abnormal pregnancy, 17-hydroxyprogesterone secretion patterns spontaneous abortion, progesterone supplementation abnormal vaginal cytology pregnancy, Harrison progesterone early pregnancy hormone monitoring, hormone levels predicting pregnancy outcome first trimester, 20alpha hydroxypregn-4-en-3-one early pregnancy, twin pregnancy progesterone levels comparison, serial hormone measurements threatened miscarriage, progesterone supplementation clinical outcome pregnancy loss, plasma steroid hormone patterns early gestation abnormal pregnancy

PMID 737159 737159 DOI 10.1111/j.1471-0528.1978.tb15855.x 10.1111/j.1471-0528.1978.tb15855.x

Cite this article

Harrison, R. F., Youssefnejadian, E., Brodovcky, H., Johnson, M., & Dewhurst, J. (1978). Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy. *British journal of obstetrics and gynaecology*, *85*(12), 927-932. https://doi.org/10.1111/j.1471-0528.1978.tb15855.x

Keywords

20-alpha-Dihydroprogesterone/blood/metabolism, Abortion, Spontaneous/blood, Female, Humans, Hydroxyprogesterones/blood/metabolism, Pregnancy, Pregnancy Complications/blood/physiopathology, Pregnancy Trimester, First, Pregnancy, Multiple, Progesterone/analogs & Derivatives/blood/metabolism, Progesterone Congeners/therapeutic Use, Hydroxyprogesterones, Progesterone Congeners, 20-alpha-Dihydroprogesterone, Progesterone

Secretion patterns of plasma-progesterone, 17-hydroxyprogesterone, and 20alpha hydroxypregn-4-en-3-one in early abnormal pregnancy

Abstract

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Cite this article

Keywords

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