Fertility and Sterility, 34(1), 17-20
Three hundred and ninety-six patients were evaluated for primary and secondary infertility between December 1976 and May 1979 at a large referral center. Timed late luteal endometrial biopsies were routinely obtained as part of the work-up and were repeated for confirmation if subsequent menses did not occur within 2 days of the expected date. If both biopsies were abnormal, a diagnosis of luteal phase defect (LPD) was made and patients were treated with vaginal progesterone suppositories for a minimum of 6 months. LPD was discovered in 32 of 396 patients (8.1%); among those patients whose infertility was not complicated by other abnormalities, 9 of 13 conceived (70%) and 7 of 13 carried to term (54%). These data suggest an incidence higher than generally recognized and a very encouraging response to replacement therapy.
Rosenberg, S. M., Luciano, A. A., & Riddick, D. H. (1980). The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone. *Fertility and sterility*, *34*(1), 17-20. https://doi.org/10.1016/s0015-0282(16)44831-4
Rosenberg SM, Luciano AA, Riddick DH. The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone. Fertil Steril. 1980;34(1):17-20. doi:10.1016/s0015-0282(16)44831-4
Rosenberg, S. M., et al. "The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone." *Fertility and sterility*, vol. 34, no. 1, 1980, pp. 17-20.
Female, Humans, Infertility, Female/drug Therapy, Luteal Phase, Pregnancy, Progesterone/administration & Dosage/therapeutic Use, Suppositories, Vagina, Suppositories, Progesterone, Americas, Biology, Connecticut, Developed Countries, Endocrine System, Hormones, Infertility, North America, Northern America, Physiology, Progestational Hormones, Progesterone, Reproduction, United States