International Journal of Fertility, 18(2), 109-115
A combination of Decadreon (dexamethasone) and Phenergan (promethazine) was tested in this collaborative study of 240 infertility patients as a means of preventing postoperative adhesion formation after simple pelvic surgery. 24 patients were lost to follow-up. The overall pregnancy rate among the 240 patients was 51.7% (124): 49% with primary infertility and 58% with secondary infertility conceived after surgery. 90 full-term deliveries were recorded, 27 spontaneous abortions occurred, and 7 ectopic gestations were conceived. In all, 31 cases were reinspected for various reasons after the drug treatment postsurgery; 42% showed no adhesions, 23% showed minimal adhesions, and 35% had significant adhesions. Complications coincident with use of the combined medication were seen in 2.2% (11 of 240) patients. Though this study lacked controls, the authors feel thta the use of corticosteroids postoperatively after pelvic intervention may control the numbers of adhesions which form postoperatively.
Horne, H. W., Clyman, M. J., Debrovner, C., Griggs, G., Kistner, R. W., Kosasa, T. S., Stevenson, C. S., & Taymor, M. L. (1973). The prevention of postoperative pelvic adhesions following conservative operative treatment for human infertility. A final 3-year follow-up report. *International journal of fertility*, *18*(2), 109-115.
Horne HW, Clyman MJ, Debrovner C, Griggs G, Kistner RW, Kosasa TS, et al. The prevention of postoperative pelvic adhesions following conservative operative treatment for human infertility. A final 3-year follow-up report. Int J Fertil. 1973;18(2):109-115.
Horne, H. W., et al. "The prevention of postoperative pelvic adhesions following conservative operative treatment for human infertility. A final 3-year follow-up report." *International journal of fertility*, vol. 18, no. 2, 1973, pp. 109-115.
Abortion, Spontaneous, Adult, Age Factors, Dexamethasone/administration & Dosage/therapeutic Use, Fallopian Tubes/surgery, Female, Fertilization, Follow-Up Studies, Humans, Infertility, Female/surgery, Middle Aged, Ovary/surgery, Pelvis, Postoperative Complications/prevention & Control, Pregnancy, Pregnancy, Ectopic, Promethazine/administration & Dosage/therapeutic Use, Time Factors, Tissue Adhesions/prevention & Control/surgery, Uterus/surgery, Dexamethasone, Promethazine, Adhesions, Adrenal Cortex Hormones--therapeutic Use, Biology, Diseases, Endocrine System, Follow-up Studies, Hormones, Infertility, Physiology, Reproduction, Research Methodology, Signs And Symptoms, Steroid Abortifacients, Studies, Surgery--complications, Treatment