To serve as a pilot feasibility study for a randomized study of excision versus ablation in the treatment of endometriosis by (1) estimating the magnitude of change in symptoms after excision only at multiple referral centers and (2) determining the proportion of women willing to participate in a randomized trial.
Methods
We performed a multicenter prospective study of women undergoing excision for endometriosis (Canadian Task Force class II-3) at Duke University Center for Endometriosis Research & Treatment (currently the Saint Louis University Center for Endometriosis), Center for Endometriosis Care, Northshore University Health System, Memorial University (Canada), and Florida Hospital. The study comprised 100 female patients, aged 18 to 55 years, with endometriosis-suspected pelvic pain. The intervention was laparoscopic excision only of the abnormal peritoneum suspicious for endometriosis. The main outcome measures were quality of life, pelvic pain, dysmenorrhea, dyspareunia, and bowel and bladder symptoms.
Results
The mean follow-up period was 8.5 months. Excision of endometriosis showed a significant reduction in all pain scores except bowel symptoms, as well as significant improvement in quality of life. Of the patients, 84% were willing to participate in a randomized study.
Conclusions
Quality of life is a needed primary outcome for any randomized study comparing excision versus ablation. A multicenter comparative trial is feasible, although quality assurance would have to be addressed. Patients were willing to be randomized even at surgical referral centers.
endometriosis excision pilot multicenter study, endometriosis excision versus ablation, surgical excision endometriosis symptom outcomes, laparoscopic excision endometriosis feasibility, endometriosis referral center surgical outcomes, randomized study endometriosis surgery pilot, excision surgery endometriosis symptom relief, multicenter endometriosis surgical trial, endometriosis treatment surgical technique comparison
PMID 23743377 23743377 DOI 10.4293/108680812X13517013317833 10.4293/108680812X13517013317833 Yeung Jr et al. 2013, Yeung Jr 2013
Cite this article
Yeung, P., Tu, F., Bajzak, K., Lamvu, G., Guzovsky, O., Agnelli, R., Peavey, M., Winer, W., Albee, R., & Sinervo, K. (2013). A pilot feasibility multicenter study of patients after excision of endometriosis. JSLS : Journal of the Society of Laparoendoscopic Surgeons, 17(1), 88-94. https://doi.org/10.4293/108680812X13517013317833
Yeung P, Tu F, Bajzak K, Lamvu G, Guzovsky O, Agnelli R, et al. A pilot feasibility multicenter study of patients after excision of endometriosis. JSLS. 2013;17(1):88-94. doi:10.4293/108680812X13517013317833
Yeung, P., et al. "A pilot feasibility multicenter study of patients after excision of endometriosis." JSLS : Journal of the Society of Laparoendoscopic Surgeons, vol. 17, no. 1, 2013, pp. 88-94.
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