Fertility and Sterility, 76(2), 394-396
To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles.
Prospective, randomized study.
Patients undergoing IVF-ET in our Centers.
PATIENT(S): The inclusion criteria were the use of GnRH down-regulation and aged <40 years.
INTERVENTION(S): A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily).
MAIN OUTCOME MEASURE(S): The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy.
RESULT(S): No difference was found in the main outcome parameters considered.
CONCLUSION(S): Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.
Costabile, L., Gerli, S., Manna, C., Rossetti, D., Di Renzo, G. C., & Unfer, V. (2001). A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. *Fertility and sterility*, *76*(2), 394-396. https://doi.org/10.1016/s0015-0282(01)01901-x
Costabile L, Gerli S, Manna C, Rossetti D, Di Renzo GC, Unfer V. A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril. 2001;76(2):394-396. doi:10.1016/s0015-0282(01)01901-x
Costabile, L., et al. "A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles." *Fertility and sterility*, vol. 76, no. 2, 2001, pp. 394-396.
17 alpha-Hydroxyprogesterone Caproate, Adult, Embryo Transfer, Female, Fertilization in Vitro, Humans, Hydroxyprogesterones/therapeutic Use, Infertility, Female/drug Therapy, Injections, Intramuscular, Male, Outcome Assessment, Health Care, Pregnancy, Progesterone/therapeutic Use, Prospective Studies, Hydroxyprogesterones, 17 alpha-Hydroxyprogesterone Caproate, Progesterone,