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beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland

Guillemin R et al., 1977

Science (New York, N.Y.), 197(4311), 1367-1369

DOI 10.1126/science.197601 PMID 197601

Abstract

The opiate-like peptide beta-endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long-term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues. Conversely, administration of the synthetic glucocorticoid dexamethasone inhibits the secretion of both adrenocorticotropin and beta-endorphin. Thus, both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin.

Topics

Reproductive Endocrinology > Neuroendocrinology > Endorphin-ACTH AxisReproductive Endocrinology > Pituitary > Hormone Co-secretionResearch Methodology > Basic Science > Neuroendocrine Mechanisms
beta-endorphin ACTH concomitant pituitary secretion, Guillemin beta-endorphin adrenocorticotropin co-secretion stress, POMC proopiomelanocortin ACTH endorphin common precursor, corticotropin releasing factor beta-endorphin ACTH secretion, dexamethasone inhibition ACTH beta-endorphin secretion, stress response pituitary endorphin ACTH adrenalectomy, opioid peptide hypothalamic pituitary adrenal axis, circulating beta-endorphin functional role reproductive implications, adenohypophysis co-secretion ACTH beta-endorphin regulatory mechanisms, endogenous opioid peptide pituitary secretion glucocorticoid feedback
PMID 197601 197601 DOI 10.1126/science.197601 10.1126/science.197601

Cite this article

Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977). beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. *Science (New York, N.Y.)*, *197*(4311), 1367-1369. https://doi.org/10.1126/science.197601

Keywords

Adrenocorticotropic Hormone/blood/metabolism, Amino Acid Sequence, Animals, Corticotropin-Releasing Hormone/pharmacology, Endorphins/blood/metabolism, Hypophysectomy, Male, Peptides/metabolism, Pituitary Gland/metabolism, Protein Precursors/metabolism, Rats, Stress, Physiological/blood, Time Factors, Endorphins, Peptides, Protein Precursors, Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone

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