Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone

Knobil E; Plant TM; Wildt L; Belchetz PE; Marshall G

doi:10.1126/science.6766566

Reproductive Endocrinology · Neuroendocrinology

Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone

Knobil E, Plant TM, Wildt L, Belchetz PE, Marshall G

Published March 21, 1980 Science (New York, N.Y.), 207(4437), 1371-1373

DOI 10.1126/science.6766566 PMID 6766566

Abstract

In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory mestrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days on the average, by a preovulatory surge) is not directed by alterations in hypothalamic gonadotropin-releasing hormone secretion but by the ebb and flow of ovarian estrogens acting directly on the pituitary gland.

Topics

Reproductive Endocrinology › Neuroendocrinology › Hypothalamic Pituitary Axis · Menstrual Cycle › Cycle Physiology › Hormonal Regulation

PMID 6766566 6766566 DOI 10.1126/science.6766566 10.1126/science.6766566 Knobil et al. 1980, Knobil 1980

Keywords

Animals, Castration, Estradiol/pharmacology, Female, Gonadotropin-Releasing Hormone/physiology, Haplorhini, Hypothalamus/physiology, Macaca/physiology, Macaca Mulatta/physiology, Menstruation/drug Effects, Pituitary Gland/physiology, Species Specificity, Gonadotropin-Releasing Hormone, Estradiol

Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone

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