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Estrogen carcinogenesis in breast cancer

Yager JD et al., 2006

The New England Journal of Medicine, 354(3), 270-282

DOI 10.1056/NEJMra050776 PMID 16421368

Abstract

Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone participate in the pathogenesis of breast cancer.

Topics

Reproductive Endocrinology > Estrogen > CarcinogenesisGeneral OB/GYN > Breast Cancer > Estrogen-Mediated RiskReproductive Endocrinology > Hormone Metabolism > Estrogen Metabolites
estrogen carcinogenesis breast cancer pathogenesis, estrogen metabolites genotoxic mutagenic breast cancer, estrogen exposure breast cancer risk mechanisms, Yager Davidson estrogen breast cancer review, hormonal carcinogenesis estrogen tissue growth stimulation, estrogen metabolism reactive intermediates breast cancer, endogenous estrogen breast cancer molecular mechanisms, estrogen receptor mediated proliferation malignancy, catechol estrogen DNA damage breast neoplasia, hormonal risk factors breast cancer etiology
PMID 16421368 16421368 DOI 10.1056/NEJMra050776 10.1056/NEJMra050776

Cite this article

Yager, J. D., & Davidson, N. E. (2006). Estrogen carcinogenesis in breast cancer. *The New England journal of medicine*, *354*(3), 270-282. https://doi.org/10.1056/NEJMra050776

Keywords

Carcinogens, Estrogens, Receptors, Estrogen

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