The aim of this study was to evaluate the associations between vasomotor symptoms ([VMS] hot flushes or flashes and night sweats) and markers of cardiovascular risk.
Methods
Healthy postmenopausal women in a randomized controlled trial of progesterone for VMS recorded VMS frequency in the Daily Menopause Diary for 28 days at baseline. Accepted risks for cardiovascular disease were measured: body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), blood pressure (BP), endothelial function by venous occlusion plethysmography, fasting lipids, glucose, high-sensitivity C-reactive protein, albumin, and D-dimer. Relationships between risk variables and VMS frequency (24 h, day and night) were assessed by univariate and multivariate robust regressions with adjustment for age and WHtR.
Results
Data were available for 145 healthy, nonsmoking women without heart disease, hypertension, or diabetes who were 1 to 11 years past their final menstruation and were aged 43 to 65 years, with a mean (SD) BMI of 25.0 (2.9) kg/m and WC of 79.1 (7.1) cm. Anthropometric variables (BMI, WC, and WHtR) were significantly negatively associated with total (24-h day) VMS frequency and with day VMS but not with night VMS frequency. Systolic BP decreased with greater 24-hour VMS frequency, and both systolic and diastolic BPs were inversely related to day but not night VMS frequency. Albumin was positively associated with night VMS frequency but not with day or 24-hour VMS frequency. Other variables showed little association with VMS frequency.
Conclusions
Hot flushes, but not night sweats, were associated with lower cardiovascular risk factors in these healthy postmenopausal women. Future research should differentiate night sweats from hot flushes.
hot flushes night sweats cardiovascular risk markers menopause, Prior JC vasomotor symptoms cardiovascular disease postmenopausal, hot flashes versus night sweats cardiovascular associations, body mass index waist circumference vasomotor symptoms, Hitchcock Prior VMS cardiovascular risk postmenopause, blood pressure endothelial function menopausal vasomotor symptoms, day versus night vasomotor symptoms health outcomes, healthy postmenopausal women VMS anthropometric measures, C-reactive protein D-dimer menopause hot flashes, venous occlusion plethysmography endothelial function menopause
PMID 22781788 22781788 DOI 10.1097/gme.0b013e31825541cc 10.1097/gme.0b013e31825541cc
Cite this article
Hitchcock, C. L., Elliott, T. G., Norman, E. G., Stajic, V., Teede, H., & Prior, J. C. (2012). Hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women. Menopause (New York, N.Y.), 19(11), 1208-1214. https://doi.org/10.1097/gme.0b013e31825541cc
Hitchcock CL, Elliott TG, Norman EG, Stajic V, Teede H, Prior JC. Hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women. Menopause. 2012;19(11):1208-1214. doi:10.1097/gme.0b013e31825541cc
Hitchcock, C. L., et al. "Hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women." Menopause (New York, N.Y.), vol. 19, no. 11, 2012, pp. 1208-1214.
Keywords
Biomarkers, Progesterone, C-Reactive Protein
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