0 My Account

Mefenamic acid in the treatment of premenstrual syndrome

Mira M et al., 1986

Obstetrics and Gynecology, 68(3), 395-398

DOI 10.1097/00006250-198609000-00022 PMID 3526218

Abstract

The use of mefenamic acid in the treatment of premenstrual syndrome (PMS) was investigated in 15 women over six menstrual cycles. A randomized, double-blind, cross-over, placebo-controlled design was used to overcome the methodologic criticisms of other medication trials in this condition. Mefenamic acid significantly improved many of the physical, mood, and performance symptoms associated with PMS. The physical symptoms that showed marked improvement were fatigue, headache, and general aches and pains (P less than .001). Most mood symptoms were improved, the most significant being freedom from mood swings (P less than .005).

Topics

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentResearch Methodology > Clinical Trials > Randomized Crossover DesignGeneral OB/GYN > Menstrual Disorders > PMS Management
mefenamic acid premenstrual syndrome treatment, PMS pharmacological treatment randomized controlled trial, mefenamic acid mood symptoms premenstrual syndrome, NSAID treatment premenstrual physical symptoms fatigue headache, double blind crossover placebo controlled PMS medication trial, prostaglandin inhibitor premenstrual syndrome management, mefenamic acid PMS mood swings physical symptoms, Fraser IS premenstrual syndrome mefenamic acid, anti-inflammatory treatment menstrual cycle mood performance, premenstrual syndrome drug therapy evidence based
PMID 3526218 3526218 DOI 10.1097/00006250-198609000-00022 10.1097/00006250-198609000-00022

Cite this article

Mira, M., McNeil, D., Fraser, I. S., Vizzard, J., & Abraham, S. (1986). Mefenamic acid in the treatment of premenstrual syndrome. *Obstetrics and gynecology*, *68*(3), 395-398. https://doi.org/10.1097/00006250-198609000-00022

Keywords

Adult, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Mefenamic Acid/adverse Effects/therapeutic Use, Menstrual Cycle, Premenstrual Syndrome/drug Therapy, Prospective Studies, Mefenamic Acid

Related articles

Treatment of premenstrual syndrome with alprazolam: results of a double-blind, placebo-controlled, randomized crossover clinical trial
Smith S et al., 1987 Obstetrics and Gynecology

A double-blind, placebo-controlled, randomized multiple crossover study was designed to determine the effectiveness of alprazolam in the treatment of premenstrual syndrome. Patients maintained daily d...

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentResearch Methodology > Clinical Trials > Randomized Crossover DesignMenstrual Cycle > Premenstrual Syndrome > Anxiolytic Therapy

Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial
Snabes MC et al., 1997 Obstetrics and Gynecology

OBJECTIVE: To assess the effect of estradiol (E2) replacement therapy on cardiac structure and function in healthy postmenopausal women. METHODS: We conducted a randomized, double-blind, placebo-cont...

Perimenopause/Menopause > Hormone Therapy > Estradiol ReplacementPerimenopause/Menopause > Cardiovascular Health > Cardiac Structure and FunctionResearch Methodology > Clinical Trials > Randomized Crossover Design

Clinical trial of naltrexone in premenstrual syndrome
Chuong CJ et al., 1988 Obstetrics and Gynecology

Twenty women with the diagnosis of premenstrual syndrome (PMS) participated in a double-blind, placebo-controlled, crossover study to evaluate the efficacy of naltrexone, an oral opiate antagonist. Th...

Menstrual Cycle > Premenstrual Syndrome > Pharmacological TreatmentMenstrual Cycle > Premenstrual Syndrome > Opioid SystemResearch Methodology > Clinical Trials > Crossover Design

Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women
Rosano GM et al., 2000 Journal of the American College of Cardiology

OBJECTIVES: We sought to compare the effects of estrogen/transvaginal progesterone gel with estrogen/medroxyprogesterone acetate (MPA) on exercise-induced myocardial ischemia in postmenopausal women w...

Perimenopause/Menopause > Hormone Replacement Therapy > Progesterone vs ProgestinsReproductive Endocrinology > Progesterone > Cardiovascular EffectsResearch Methodology > Clinical Trials > Randomized Crossover Design