Progesterone therapy in women with complex partial and secondary generalized seizures

Herzog AG

doi:10.1212/wnl.45.9.1660

Progesterone therapy in women with complex partial and secondary generalized seizures

Herzog AG, 1995

Neurology, 45(9), 1660-1662

DOI 10.1212/wnl.45.9.1660 PMID 7675223

Abstract

This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).

Topics

Reproductive Endocrinology > Progesterone Therapy > Neurological Applications Menstrual Cycle > Catamenial Conditions > Epilepsy and Seizures Reproductive Endocrinology > Hormonal Treatment > Progesterone Clinical Trials

progesterone therapy catamenial epilepsy seizure frequency, Herzog progesterone complex partial seizures women, catamenial seizure exacerbation progesterone treatment open trial, natural progesterone adjunctive therapy epilepsy women, secondary generalized seizures progesterone supplementation, hormonal therapy catamenial epilepsy menstrual cycle seizures, progesterone neurological effects anticonvulsant women, catamenial complex partial seizure frequency reduction progesterone, menstrual cycle related epilepsy hormonal treatment, progesterone side effects asthenia depression seizure therapy

PMID 7675223 7675223 DOI 10.1212/wnl.45.9.1660 10.1212/wnl.45.9.1660

Cite this article

Herzog, A. G. (1995). Progesterone therapy in women with complex partial and secondary generalized seizures. *Neurology*, *45*(9), 1660-1662. https://doi.org/10.1212/wnl.45.9.1660

Keywords

Adolescent, Adult, Epilepsy, Complex Partial/drug Therapy, Epilepsy, Generalized/drug Therapy, Female, Humans, Progesterone/therapeutic Use, Progesterone

Progesterone therapy in women with complex partial and secondary generalized seizures

Abstract

Topics

Cite this article

Keywords

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