Journal of Psychosomatic Research, 29(5), 489-493
Fifteen women with moderate to severe premenstrual symptoms, defined and graded according to a recently developed scoring system, took part in a double blind study of the effect of progesterone on premenstrual symptoms. The dosage was 100 mg progesterone twice daily delivered in vaginal pessaries. The women were improved with a statistically significant decrease in their scores by progesterone as well as by placebo treatment. There was no statistically significant difference between the two regimes.
Andersch, B., & Hahn, L. (1985). Progesterone treatment of premenstrual tension--a double blind study. *Journal of psychosomatic research*, *29*(5), 489-493. https://doi.org/10.1016/0022-3999(85)90082-0
Andersch B, Hahn L. Progesterone treatment of premenstrual tension--a double blind study. J Psychosom Res. 1985;29(5):489-493. doi:10.1016/0022-3999(85)90082-0
Andersch, B., and L. Hahn. "Progesterone treatment of premenstrual tension--a double blind study." *Journal of psychosomatic research*, vol. 29, no. 5, 1985, pp. 489-493.
Adult, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Middle Aged, Pessaries, Premenstrual Syndrome/drug Therapy, Progesterone/administration & Dosage/therapeutic Use, Vagina, Progesterone,