Thirty-one women with severe premenstrual syndrome had low sex hormone binding globulin (SHBG) binding capacities 30.2 +/- 9.4 nmol DHT bound/l. The SHBG binding capacities rose when they were treated with three different doses of progesterone. On 400 mg (17 women) SHBG level was 45.11 +/- 11.80. On 800 mg (8 women) SHBG binding capacity rose to 64.75 +/- 14.30 and on the six women who took 1200 mg progesterone daily SHBG binding capacity was 78.5 +/- 23.10. These results are discussed.
PMID 6538615 6538615 DOI 10.1016/0022-4731(84)90249-8 10.1016/0022-4731(84)90249-8
Cite this article
Dalton, M. E. (1984). The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. *Journal of steroid biochemistry*, *20*(1), 437-439. https://doi.org/10.1016/0022-4731(84)90249-8
Dalton ME. The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. J Steroid Biochem. 1984;20(1):437-439. doi:10.1016/0022-4731(84)90249-8
Dalton, M. E. "The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome." *Journal of steroid biochemistry*, vol. 20, no. 1, 1984, pp. 437-439.
Keywords
Female, Humans, Premenstrual Syndrome/blood/drug Therapy, Progesterone/administration & Dosage/therapeutic Use, Sex Hormone-Binding Globulin/metabolism, Sex Hormone-Binding Globulin, Progesterone
Progesterone is the most widely used treatment for premenstrual syndrome. To answer definitely the question of whether progesterone suppositories are effective for the treatment of premenstrual syndro...
Van der Meer YG et al., 1983Journal of Psychosomatic Obstetrics & Gynecology
A double-blind cross-over placebo controlled trial was carried out to compare progesterone 200 mg with a placebo, both given in rectal suppositories, in 20 patients with the pre-menstrual syndrome (PM...
Microsomal membranes sedimented at 40 000 g were prepared from human myometrium samples. The progesterone binding properties of microsomal suspensions were determined by incubating microsomes and [3H]...
Martin F et al., 1975Journal of Steroid Biochemistry
Progesterone metabolites and estriol were determined in urine and faeces collected daily from three pregnant women (33–37 weeks) before and during ampicillin administration (2 g/day orally).
Two of th...