Fertility and Sterility, 66(2), 220-222
To investigate the effects of low dose flutamide (250 mg/d) on hirsutism score and hormone levels in women with hirsutism.
Nonrandomized, prospective clinical trial.
Forty-one patients with moderate-severe hirsutism were included in the study.
Hirsute patients received 250 mg/d flutamide for a period of 6 months.
Hirsutism score, FSH, LH, E2, total T, free T, androstenedione, DHEAS, PRL, 17-hydroxyprogesterone, and sex hormone-binding globulin levels were detected in all the patients before treatment and every 3 months during treatment.
Treatment with the antiandrogen flutamide resulted in a particularly rapid and marked decrease in the hirsutism score, which decreased from 17.48 +/- 5.35 to 5.07 +/- 2.89 after 6 months. No significant changes in the levels of hormone and no serious side effects were observed in the study.
The low-dose flutamide, 250 mg/d, is a cost-effective drug in the treatment of hirsutism. Low-dose flutamide may be used in place of high-dose flutamide, 500 to 750 mg/d.
Bayram, F., Sahin, Y., Keleştimur, F., Tutuş, A., Ayata, D., & Müderris, I. I. (1996). The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. *Fertility and sterility*, *66*(2), 220-222. https://doi.org/10.1016/s0015-0282(16)58442-8
Bayram F, Sahin Y, Keleştimur F, Tutuş A, Ayata D, Müderris II. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertil Steril. 1996;66(2):220-222. doi:10.1016/s0015-0282(16)58442-8
Bayram, F., et al. "The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism." *Fertility and sterility*, vol. 66, no. 2, 1996, pp. 220-222.
Adolescent, Adult, Androgen Antagonists/therapeutic Use, Androstenedione/blood, Dose-Response Relationship, Drug, Estrogens/blood, Female, Flutamide/therapeutic Use, Follicle Stimulating Hormone/blood, Hirsutism/blood/drug Therapy, Humans, Luteinizing Hormone/blood, Progesterone/blood, Prospective Studies, Testosterone/blood, Androgen Antagonists, Estrogens, Testosterone, Androstenedione, Progesterone, Flutamide, Luteinizing Hormone, Follicle Stimulating Hormone,