Abstract
Objective To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles.
Design Retrospective study.
Setting Tertiary referral center.
PATIENT(S): In 26 cycles, 24 patients underwent ovulation induction or superovulation with either clomiphene citrate or hMG.
INTERVENTION(S): Selective follicle aspiration was performed before hCG administration.
MAIN OUTCOME MEASURE(S): Clinical pregnancy rate and numbers of multiple pregnancies.
RESULT(S): A mean number of 4.5 follicles with a diameter > or =15 mm and a mean number of 4.5 follicles with a diameter < or =14 mm were observed before hCG administration. A mean number of 2.3 follicles with a diameter > or =15 mm and a mean number of 1.8 follicles with a diameter < or =14 mm were aspirated before the hCG administration. Seven singleton pregnancies (26.9% per cycle) ensued from the treatment.
CONCLUSION(S): Aspiration of supernumerary follicles after ovulation induction or superovulation seems to be a valid approach to avoid multiple pregnancies without affecting pregnancy rate.
follicular reduction avoid multiple pregnancy ovulation induction, supernumerary follicle aspiration before hCG administration, multiple pregnancy prevention ovulation induction cycle, selective follicle aspiration clomiphene hMG superovulation, Albano follicular reduction multiple pregnancy prevention, ovulation induction singleton pregnancy selective aspiration, multifollicular response management ovulation induction safety, preovulatory follicle aspiration multiple gestation avoidance, clomiphene citrate hMG superovulation multiple pregnancy risk, cycle cancellation alternative follicle reduction strategy
PMID 11591420 11591420 DOI 10.1016/s0015-0282(01)02379-2 10.1016/s0015-0282(01)02379-2
Keywords
Adult, Female, Follicular Phase, Humans, Ovarian Follicle/surgery, Ovulation Induction/adverse Effects, Pregnancy, Pregnancy Rate, Pregnancy, Multiple, Retrospective Studies, Suction