Endocrinology, 71(3), 448-451
A new progestational steroid, the acetophenone derivative of 16α,17α;- dihydroxyprogesterone, was compared with several progestogens for masculinizing effects on the offspring of rats treated during pregnancy. The results were similar to those obtained with progesterone and 17α-hydroxyprogesterone caproate: this new steroid did not alter the normal male:female sex ratio and did not virilize the internal or external sex structures of the newborn. The present results confirm those of others in finding that 6α-methyl-17α-hydroxyprogesterone acetate, 17α-ethinyl-19-nortestosterone and 17aethinyl- 19-nortestosterone acetate increased the number of male and intersex offspring, as determined by ano-genital measurements and masculinization of internal and external sex organs.
Lerner, L. J., Dephillipo, M., Yiacas, E., Brennan, D., & Borman, A. (1962). Comparison of the acetophenone derivative 16alpha,17alpha-dihydroxyprogesterone with other progestational steroids for masculinization of the ratfetus. *Endocrinology*, *71*(3), 448-451. https://doi.org/10.1210/endo-71-3-448
Lerner LJ, Dephillipo M, Yiacas E, Brennan D, Borman A. Comparison of the acetophenone derivative 16alpha,17alpha-dihydroxyprogesterone with other progestational steroids for masculinization of the ratfetus. Endocrinology. 1962;71(3):448-451. doi:10.1210/endo-71-3-448
Lerner, Leonard J., et al. "Comparison of the acetophenone derivative 16alpha,17alpha-dihydroxyprogesterone with other progestational steroids for masculinization of the ratfetus." *Endocrinology*, vol. 71, no. 3, 1962, pp. 448-451.
Acetophenones, Algestone, Androgens/pharmacology, Female, Fetus/pharmacology, Humans, Progesterone/analogs & Derivatives, Steroids, Virilism, Acetophenones, Androgens, Steroids, Algestone, Progesterone, Acetophenone, ANDROGENS/pharmacology, FETUS/pharmacology, PROGESTERONE/related Compounds