The Medical and Surgical Practice of NaProTECHNOLOGY, 307-334, 2004
Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones
Author affiliations
- Pope Paul VI Institute for the Study of Human Reproduction, Omaha, Nebraska. ROR
The Medical and Surgical Practice of NaProTECHNOLOGY, 307-334, 2004
Hilgers distinguishes isomolecular hormones -- molecules structurally identical to endogenous estradiol and progesterone -- from heteromolecular artimones, his term for synthetic analogues such as medroxyprogesterone acetate, norethindrone, and ethinyl estradiol, which differ in receptor binding, metabolic pathways, and systemic effects. NaProTECHNOLOGY restricts hormone therapy to isomolecular compounds administered in cycle-synchronized, physiologic doses because artimones suppress the hypothalamic-pituitary-ovarian axis, mask underlying pathology, and produce non-physiologic metabolite profiles incompatible with a restorative reproductive medicine approach.
Hilgers, T. W. (2004). Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones. *The Medical and Surgical Practice of NaProTECHNOLOGY*, 307-334.
Hilgers TW. Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones. The Medical and Surgical Practice of NaProTECHNOLOGY. 2004:307-334.
Hilgers, T. W. "Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones." *The Medical and Surgical Practice of NaProTECHNOLOGY*, 2004, pp. 307-334.