The Medical and Surgical Practice of NaProTECHNOLOGY, 307-334, 2004

Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones

Thomas W Hilgers

Author affiliations
  • Pope Paul VI Institute for the Study of Human Reproduction, Omaha, Nebraska. ROR
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Abstract

Hilgers distinguishes isomolecular hormones -- molecules structurally identical to endogenous estradiol and progesterone -- from heteromolecular artimones, his term for synthetic analogues such as medroxyprogesterone acetate, norethindrone, and ethinyl estradiol, which differ in receptor binding, metabolic pathways, and systemic effects. NaProTECHNOLOGY restricts hormone therapy to isomolecular compounds administered in cycle-synchronized, physiologic doses because artimones suppress the hypothalamic-pituitary-ovarian axis, mask underlying pathology, and produce non-physiologic metabolite profiles incompatible with a restorative reproductive medicine approach.

Topics

bioidentical hormone replacement therapy, natural progesterone vs synthetic progestin, micronized progesterone absorption, estradiol cardiovascular protection postmenopause, luteal phase progesterone support natural, oral contraceptive side effects metabolic, estriol breast cancer prevention, triple estrogen formulation compounding, vaginal progesterone first uterine pass effect, medroxyprogesterone acetate heart disease risk, progesterone cream absorption through skin, heteromolecular artimone definition, isomolecular hormone vs synthetic hormone, 19-nortestosterone progestin androgenic effects, conjugated equine estrogen metabolites, progesterone thermogenic basal body temperature, cyclic progesterone dosing schedule, endometrial hyperplasia protection progesterone, HDL cholesterol estrogen progesterone effect, progesterone receptor isoforms PR-A PR-B, steroid hormone biosynthesis pathway, pregnenolone conversion to progesterone, estrogen receptor alpha beta distribution, first pass metabolism oral estradiol, salivary progesterone monitoring luteal phase, intramuscular progesterone peak serum levels, compounding pharmacist bioidentical hormones, progesterone brain neuroprotection multiple sclerosis, vasomotor symptoms natural hormone treatment, bone mineral density estradiol transdermal

Cite this article

Hilgers, T. W. (2004). Chapter 26: Isomolecular Hormones vs Heteromolecular Artimones. *The Medical and Surgical Practice of NaProTECHNOLOGY*, 307-334.

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