Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Resseguie LJ, Hick JF, Bruen JA, Noller KL, O'Fallon WM, Kurland LT

doi:10.1016/s0015-0282(16)48490-6

Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Resseguie LJ et al., 1985

Fertility and Sterility, 43(4), 514-519

DOI 10.1016/s0015-0282(16)48490-6 PMID 3987922

Abstract

Comparison of a cohort of 988 offspring exposed in utero to exogenous progestins with a matched cohort of unexposed offspring did not result in detection of an association of congenital anomalies with exposure. The conclusions are based primarily on outcomes of pregnancy with exposure to progesterone and 17 alpha-hydroxyprogesterone caproate, and may not apply to androgenic progestins. Offspring exposed to combinations of progestins and estrogens were excluded from this study and may have a different distribution of anomalies.

Topics

Pregnancy > Medications in Pregnancy > Progestin Safety Pregnancy > Outcomes > Congenital Malformations Research Methodology > Epidemiology > Retrospective Cohort Studies

in utero progestin exposure congenital malformations, progesterone pregnancy safety birth defects, 17 alpha-hydroxyprogesterone caproate fetal safety, progestin exposure offspring congenital anomalies cohort study, Resseguie progestin exposure Olmsted County, exogenous progesterone pregnancy teratogenicity, prenatal progestogen exposure birth outcomes, hydroxyprogesterone caproate safety pregnancy malformations, progestin versus androgenic progestin fetal effects, progesterone supplementation pregnancy fetal anomalies epidemiology

PMID 3987922 3987922 DOI 10.1016/s0015-0282(16)48490-6 10.1016/s0015-0282(16)48490-6

Cite this article

Resseguie, L. J., Hick, J. F., Bruen, J. A., Noller, K. L., O'Fallon, W. M., & Kurland, L. T. (1985). Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974. *Fertility and sterility*, *43*(4), 514-519. https://doi.org/10.1016/s0015-0282(16)48490-6

Keywords

17 alpha-Hydroxyprogesterone Caproate, Abnormalities, Drug-Induced/epidemiology, Ethisterone/adverse Effects, Female, Fetal Death/epidemiology, Humans, Hydroxyprogesterones/adverse Effects, Infant, Newborn, Male, Maternal-Fetal Exchange, Medroxyprogesterone/adverse Effects, Minnesota, Norethindrone/adverse Effects, Pregnancy, Prenatal Exposure Delayed Effects, Progesterone/adverse Effects, Progestins/adverse Effects, Hydroxyprogesterones, Progestins, 17 alpha-Hydroxyprogesterone Caproate, Progesterone, Medroxyprogesterone, Ethisterone, Norethindrone

Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Abstract

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