Abstract
Objective To determine whether insulin resistance is associated with recurrent pregnancy loss (RPL).
Design Single center, case-controlled, prospective study.
Setting University-associated reproductive endocrinology clinical practice.
PATIENT(S): Seventy-four nonpregnant, nondiabetic women with RPL. Controls were 74 fertile, nonpregnant, nondiabetic women without RPL who had at least one live infant, and were matched by age, race, and body mass index (BMI).
INTERVENTION(S): Both groups consented to obtaining fasting insulin and glucose levels.
MAIN OUTCOME MEASURE(S): Insulin resistance was defined as a fasting insulin level >20 microU/mL or a fasting glucose to insulin ratio of <4.5.
RESULT(S): Among the 74 women with RPL, 20 (27.0%) demonstrated insulin resistance, whereas only 7 of 74 (9.5%) of the matched controls were insulin resistant (odds ratio 3.55; 95% confidence interval 1.40-9.01). The RPL and control groups were similar with respect to age, ethnicity, and BMI. The RPL and control groups had similar fasting glucose levels and glucose-to-insulin ratios. However, fasting insulin levels > or =20 microU/mL were statistically different between the two groups (odds ratio 3.92).
CONCLUSION(S): Women with RPL have a significantly increased prevalence of insulin resistance when compared with matched fertile controls.
insulin resistance recurrent pregnancy loss association, fasting insulin levels recurrent miscarriage, Craig Kutteh insulin resistance recurrent pregnancy loss, glucose to insulin ratio recurrent miscarriage, metabolic factors recurrent pregnancy loss case control, hyperinsulinemia miscarriage risk factor prospective study, insulin resistance unexplained recurrent pregnancy loss prevalence, fasting insulin greater than 20 pregnancy loss, BMI matched controls recurrent miscarriage insulin, insulin sensitivity reproductive outcomes recurrent loss
PMID 12215322 12215322 DOI 10.1016/s0015-0282(02)03247-8 10.1016/s0015-0282(02)03247-8
Keywords
Abortion, Habitual/etiology/physiopathology, Adult, Blood Glucose/analysis, Case-Control Studies, Fasting, Female, Humans, Insulin/blood, Insulin Resistance/physiology, Pregnancy, Prevalence, Reference Values, Blood Glucose, Insulin