Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea

Gompel A, Mauvais-Jarvis P

doi:10.1093/oxfordjournals.humrep.a136731

Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea

Gompel A et al., 1988

Human Reproduction (Oxford, England), 3(4), 473-477

DOI 10.1093/oxfordjournals.humrep.a136731

Abstract

Pulsatile administration of gonadotrophin releasing hormone (GnRH) is a very effective treatment for induction of ovulation in hypothalamic amenorrhoea (HA). Thirty-seven women have been treated for a total of 117 cycles which resulted in 42 pregnancies--four treatment failures occurred. If these cycles are excluded, the 42 pregnancies were obtained within 2.3 cycles. One twin pregnancy occurred and no hyperstimulation was observed. The treatment was administered intravenously with a dosage schedule based on the grading of HA. We concluded that pulsatile GnRH was safe and very successful in induction of pregnancy in HA. Other indications (polycystic ovary syndrome and luteal phase defect) remain much less suitable for this treatment.

Topics

Reproductive Endocrinology > Ovulation > Induction Infertility > Female Factor > Ovulatory Dysfunction Menstrual Cycle > Disorders > Amenorrhea Reproductive Endocrinology > Luteal Phase > Deficiency

pulsatile gnrh hypothalamic amenorrhea, gnrh pump ovulation induction, hypothalamic amenorrhea pregnancy outcomes, pulsatile gonadotropin releasing hormone infertility, gnrh therapy amenorrhea treatment, ovulation induction hypothalamic dysfunction, pulsatile gnrh luteal phase defect, gnrh pump fertility treatment, hypothalamic amenorrhea ovulation restoration, intravenous gnrh ovulation induction, root cause treatment hypothalamic amenorrhea

Cite this article

Gompel, A., & Mauvais-Jarvis, P. (1988). Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea. *Human reproduction (Oxford, England)*, *3*(4), 473-477. https://doi.org/10.1093/oxfordjournals.humrep.a136731

Keywords

Amenorrhea/drug Therapy/etiology, Female, Follicle Stimulating Hormone/blood, Gonadotropin-Releasing Hormone/administration & Dosage/therapeutic Use, Humans, Hypothalamic Diseases/complications, Luteinizing Hormone/blood, Ovulation Induction, Pregnancy, Gonadotropin-Releasing Hormone, Luteinizing Hormone, Follicle Stimulating Hormone,

Induction of ovulation with pulsatile GnRH in hypothalamic amenorrhoea

Abstract

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Cite this article

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