The Journal of Clinical Endocrinology and Metabolism, 51(5), 1214-1216, 1980
In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.
Leyendecker, G., Wildt, L., & Hansmann, M. (1980). Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea. *The Journal of clinical endocrinology and metabolism*, *51*(5), 1214-1216. https://doi.org/10.1210/jcem-51-5-1214
Leyendecker G, Wildt L, Hansmann M. Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea. J Clin Endocrinol Metab. 1980;51(5):1214-1216. doi:10.1210/jcem-51-5-1214
Leyendecker, G., et al. "Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea." *The Journal of clinical endocrinology and metabolism*, vol. 51, no. 5, 1980, pp. 1214-1216.
Adult, Amenorrhea/drug Therapy, Chorionic Gonadotropin/blood, Estradiol/blood, Female, Follicle Stimulating Hormone/blood, Gonadotropin-Releasing Hormone/administration & Dosage/therapeutic Use, Humans, Hypothalamus/physiopathology, Infertility, Female/drug Therapy, Injections, Intravenous, Luteinizing Hormone/blood, Ovary/physiopathology, Pregnancy, Progesterone/blood, Chorionic Gonadotropin, Gonadotropin-Releasing Hormone, Progesterone, Estradiol, Luteinizing Hormone, Follicle Stimulating Hormone