Abstract
Objective To describe the characteristics of pregnancies and children at birth resulting from IVF-ET and to assess whether they differ from those after natural conception.
Design Prospective multicenter survey.
Setting A national registry, representing 80% of all French IVF-ET activity for the period 1986 to 1990.
Patients Data on 7,024 pregnancies, 5,371 deliveries, and 6,879 newborn infants.
Interventions A form is completed for every clinical pregnancy.
Main Outcome Measures Spontaneous abortion, ectopic pregnancy, multiple pregnancy, prematurity, hypotrophy, perinatal and neonatal mortality, and congenital malformations rates.
Results The spontaneous abortion and ectopic pregnancy rates were, respectively, 17.6% and 5.8%. More than a quarter (26.8%) of the deliveries were multiple births. The preterm birth rate (29.3%), the low birth weight rate (36.2%), and the perinatal and neonatal mortality rates were higher than the national average. The rate of malformations (2.8%) was comparable with the general population (2.1%).
Conclusion Assisted conception frequently results in multiple pregnancy, and this is the main determinant of pregnancy outcome. Nevertheless, it is not the only risk factor for prematurity, which is also more frequent among IVF singleton newborn. The prevalence of congenital malformations is not higher than after natural conception.
IVF pregnancy outcomes French national registry multicenter, in vitro fertilization multiple pregnancy prematurity rates, IVF singleton preterm birth risk factor analysis, assisted reproduction ectopic pregnancy spontaneous abortion rate, IVF newborn congenital malformation rate comparison natural conception, FIVNAT French IVF registry pregnancy birth outcomes, IVF low birth weight perinatal neonatal mortality, multiple birth IVF pregnancy outcome determinant, assisted conception singleton prematurity risk factors, IVF ET clinical pregnancy outcome prospective survey
PMID 7672146 7672146 DOI 10.1016/s0015-0282(16)57850-9 10.1016/s0015-0282(16)57850-9
Keywords
Birth Rate, Congenital Abnormalities/epidemiology, Data Collection, Female, Fertilization in Vitro, France, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Labor, Obstetric, Pregnancy, Pregnancy Outcome, Pregnancy, Ectopic/epidemiology, Pregnancy, Multiple, Prospective Studies, Registries