Abstract
Objective To confirm that hCG levels in follicular fluid and serum would be comparable between i.m. and s.c. administration of purified hCG.
Design In a prospective study, serum and follicular fluid levels of hCG after an i.m. or s.c. injection of 10,000 IU of hCG were evaluated 36 hours after injection, that is, at the time of oocyte retrieval.
Setting This study was carried out in a university-affiliated IVF program.
PATIENT(S): Forty women undergoing oocyte retrieval were entered into the study at the time of egg retrieval, that is, 36 hours after hCG administration.
INTERVENTION(S): S.c. or i.m. injection of hCG.
MAIN OUTCOME MEASURE(S): Serum and follicular fluid concentrations of hCG were evaluated 36 hours after injection at the time of oocyte retrieval.
RESULT(S): There was a significantly higher serum hCG level in the s.c. group (348.6 +/- 98 IU/L) vs. the i.m. group (259.0 +/- 115 IU/L) and a significantly higher follicular fluid hCG level in the s.c. vs. the i.m. group (233.5 +/- 85 vs. 143.4 +/- 134 IU/L).
CONCLUSION(S): After purified hCG administration via the s.c. route, both serum and follicular fluid levels are greater compared with the i.m. route.
subcutaneous vs intramuscular hCG IVF cycle oocyte retrieval, hCG administration route serum follicular fluid levels, purified hCG subcutaneous injection IVF prospective study, human chorionic gonadotropin intramuscular subcutaneous comparison, follicular fluid hCG concentration oocyte retrieval 36 hours, Stelling subcutaneous hCG IVF serum levels, 10000 IU hCG injection route pharmacokinetics IVF, subcutaneous hCG higher serum levels follicular fluid, hCG bioavailability route of administration in vitro fertilization, IVF trigger shot subcutaneous intramuscular hCG comparison
PMID 12749424 12749424 DOI 10.1016/s0015-0282(02)04918-x 10.1016/s0015-0282(02)04918-x
Keywords
Adult, Chorionic Gonadotropin/administration & Dosage/blood/metabolism, Female, Fertilization in Vitro/methods, Follicle Stimulating Hormone/metabolism, Follicular Fluid/metabolism, Humans, Injections, Intramuscular, Injections, Subcutaneous, Ovarian Follicle/metabolism, Ovulation Induction/methods/standards, Pregnancy, Prospective Studies, Chorionic Gonadotropin, Follicle Stimulating Hormone