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The effect of pre-pregnancy hair dye exposure on infant birth weight: a nested case-control study

Qingzhi Hou, Yuanxin Huang, Chao Jiang, Y Jiang, Meiling Li, Wen Meng, Zengnan Mo, Xiaolian Qin, Qiuyan Wang, Xiaobo Yang, Juan Ye, Hao Zhang, Yue Zhang

Open Access
  • Guangxi University ROR
  • Shanghai Jiao Tong University ROR
  • Zhengzhou University ROR
  • Guigang City People's Hospital ROR
  • University of Utah ROR

BMC Pregnancy and Childbirth, 18(1), 144

DOI 10.1186/s12884-018-1782-5 PMID 29743046

Abstract

Background

Limited evidences were reported about the risk of pre-pregnancy hair dye use or irregular menstruation with abnormal birth weight during pregnancy, and their joint effects were also unknown. The aim of our study was to explore whether the pre-pregnancy exposure of hair dye and irregular menstruation were associated with the risk of abnormal birth weight.

Methods

We conducted a nested case-control study from a prospective cohort of 6203 pregnant women. Low birth weight study included 315 mother-infant pairs (105 LBW cases and 210 matched controls), and macrosomia study included 381 mother-infant pairs (127 macrosomia cases and 254 matched controls). Meanwhile, lifestyle information including hair dying custom and menstrual history were collected by face-to-face questionnaires and birth outcomes were extracted from the medical records. The logistic regressions models were used to analyze the join effect of irregular menstruation and hair dye use.

Results

Pre-pregnancy hair dye use was associated with increased risk of LBW (adjusted OR = 1.71, 95% CI: 1.01-2.92, P = 0.048). Irregular menstruation had high risk of LBW (adjusted OR = 2.79, 95% CI: 1.53-5.09, P = 0.001) and macrosomia (adjusted OR = 1.93, 95% CI: 1.09-3.44, P = 0.023). Additionally, in the LBW study, women who used hair dye with pre-pregnancy BMI < 18.5 kg/m(2) had higher OR than those with only one risk factor (3.07 vs 2.53, P (trend) = 0.015), and women with both hair dye use and irregular menstruation also had higher risk than those with only one factor (4.53 vs 2.07, P (trend) = 0.05). Moreover, in macrosomia study, women with irregular menstruation and pre-pregnancy BMI ≥ 24 kg/m(2) had higher risk than those with one factor (13.31 vs 2.09, P (trend) = 0.001).

Conclusion

Our study showed that either pre-pregnancy hair dye use or irregular menstruation was associated with abnormal birth weight, especially, their joint effects could furthermore increase the risk of low birth weight infants when these two factors existed simultaneously.

Topics

Pregnancy > Environmental Exposure > Hair Dye and Birth WeightMenstrual Cycle > Irregular Menstruation > Chemical Exposure InteractionResearch Methodology > Case-Control Study > Environmental Reproductive Risk
Jiang Hou Huang pre-pregnancy hair dye exposure infant birth weight nested case-control, hair dye chemical exposure low birth weight macrosomia irregular menstruation interaction, pre-pregnancy environmental exposure hair color cosmetic chemicals fetal growth, BMC Pregnancy Childbirth 2018 hair dye birth weight case-control Chinese cohort, irregular menstruation hair dye joint effect abnormal birth weight risk, aromatic amines p-phenylenediamine hair dye endocrine disruption pregnancy outcome, pre-conception chemical exposure birth weight odds ratio adjusted confounders, small for gestational age large for gestational age hair dye reproductive toxicity, maternal occupational cosmetic chemical exposure fetal growth restriction evidence, hair dye use pregnancy outcome environmental reproductive epidemiology China
PMID 29743046 29743046 DOI 10.1186/s12884-018-1782-5 10.1186/s12884-018-1782-5

Cite this article

Jiang, C., Hou, Q., Huang, Y., Ye, J., Qin, X., Zhang, Y., Meng, W., Wang, Q., Jiang, Y., Zhang, H., Li, M., Mo, Z., & Yang, X. (2018). The effect of pre-pregnancy hair dye exposure on infant birth weight: a nested case-control study. *BMC pregnancy and childbirth*, *18*(1), 144. https://doi.org/10.1186/s12884-018-1782-5

Keywords

Adult, Birth Weight, Body Mass Index, Case-Control Studies, Female, Fetal Macrosomia/epidemiology, Hair Dyes, Humans, Infant, Low Birth Weight, Infant, Newborn, Menstruation Disturbances/epidemiology, Pregnancy, Prospective Studies, Surveys and Questionnaires, Young Adult, Hair Dyes, Hair Dye Use, Irregular Menstruation, Low Birth Weight Infants, Macrosomia, Pre-pregnancy BMI

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