The luteinized unruptured follicle syndrome is a form of anovulation and a subtle cause of female infertility. The syndrome cannot be diagnosed by traditional progesterone-dependent ovulation detection methods. Without the use of invasive procedures or sophisticated equipment, the luteinized unruptured follicle syndrome may go unnoticed. The patient diagnosed as ovulatory, on the basis of traditional ovulation detection methods, who does not conceive may be experiencing the luteinized unruptured follicle syndrome, and thus infertility. The syndrome's incidence, detection, etiology, and treatment are described.
LeMaire GS (1987). The luteinized unruptured follicle syndrome: anovulation in disguise. *Journal of obstetric, gynecologic, and neonatal nursing : JOGNN*, *16*(2), 116-120. https://doi.org/10.1111/j.1552-6909.1987.tb01446.x
LeMaire GS. The luteinized unruptured follicle syndrome: anovulation in disguise. J Obstet Gynecol Neonatal Nurs. 1987;16(2):116-120. doi:10.1111/j.1552-6909.1987.tb01446.x
LeMaire GS. "The luteinized unruptured follicle syndrome: anovulation in disguise." *Journal of obstetric, gynecologic, and neonatal nursing : JOGNN*, vol. 16, no. 2, 1987, pp. 116-120.
DlJ. ring the last stage of puberty, the hypothalamic-pituitary-ovarian axis acquires the ability to respond to high levels of estradiol; this results in a sharp increase in the pituitary output of lu...
Hilgers TW et al., 1992Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
The empty follicle syndrome was assessed using transvaginal ultrasonography in a group of 152 consecutive women with unmedicated menstrual cycles being studied because of primary or secondary infertil...
Check JH et al., 1987International Journal of Fertility
Controversy still exists as to the proper therapy of luteal phase defects. Some advocate using drugs to improve follicular dynamics, e.g., clomiphene citrate, while others treat luteal phase defects w...
A clinical description of luteinized unruptured follicles is presented. This abnormality in ovulation is characterized by normal endocrinologic presumptive signs of ovulation: biphasic basal body temp...