Katz, E. (1988). The luteinized unruptured follicle and other ovulatory dysfunctions. Fertility and Sterility, 50(6), 839-850. https://doi.org/10.1016/s0015-0282(16)60359-x
Katz E. The luteinized unruptured follicle and other ovulatory dysfunctions. Fertil Steril. 1988;50(6):839-850. doi:10.1016/s0015-0282(16)60359-x
Katz, E. "The luteinized unruptured follicle and other ovulatory dysfunctions." Fertility and Sterility, vol. 50, no. 6, 1988, pp. 839-850.
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Luteinized unruptured follicles occur in fertile women too
A 1988 review of studies in women with and without infertility found luteinized unruptured follicles also occur in fertile women. Reported rates ran from 9% to 55%. The egg is thought to stay trapped in these follicles. The author judged the condition probably not a syndrome.
Key Findings
Studies of fertile women reported luteinized unruptured follicles at rates from 9% to 55%. Studies of infertile women reported rates from 6% to 83%, the highest in women with endometriosis.
An ultrasound study monitored 37 women with unexplained infertility for 100 cycles. Luteinized unruptured follicles appeared in 57% of the cycles.
Over 2 to 36 months, 9 of 22 women (41%) with luteinized unruptured follicle cycles and 2 of 17 (12%) with ovulatory cycles became pregnant spontaneously. No life-table analysis was made.
Laparoscopy found luteinized unruptured follicles in 23 of 29 women with endometriosis (79%) and in 1 of 16 infertile controls (6.3%). Other studies gave conflicting results.
In monkeys with grafted endometrial tissue, those with moderate or severe disease had luteinized unruptured follicles in 46%-50% of cycles. Controls and mild disease had none.
Interpretation
This 1988 review gathers earlier studies on luteinized unruptured follicles. The condition showed up in both fertile and infertile women. Rates were highest in women with endometriosis. Some women got pregnant during cycles thought to have the condition. In monkeys with endometriosis, worse disease meant more cycles with the condition. The findings support larger studies on how this condition affects fertility.
RRM Context
Doctors have long assumed ovulation when a temperature rise or progesterone appears. This review treats those signs as proof of luteinization only. Real proof of egg release would need a found egg or a pregnancy outside the ovary. Restorative reproductive medicine reads charted signs as an ovulatory event and looks for the cause when a couple with such a chart has not conceived.
Our editorial summary of this paper, not the article's abstract.
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