What fertility supplements have evidence behind them (CoQ10, vitamin D, DHEA, inositol)?

RRM uses targeted nutritional testing to identify specific deficiencies before recommending supplements, focusing on CoQ10, vitamin D, folate, and omega-3 fatty acids based on individual metabolic needs and documented evidence.

RRM's Evidence-Based Supplement Approach

Restorative Reproductive Medicine evaluates nutritional status through targeted testing before any supplement recommendations. This means measuring vitamin D levels, assessing MTHFR gene variants for folate metabolism, and evaluating antioxidant markers. The goal is addressing actual nutritional barriers to conception rather than following generic protocols.

CoQ10 and its active form ubiquinol show measurable benefits for both egg and sperm quality in published research. Vitamin D deficiency affects 67-85% of women with PCOS and correlates with endometriosis severity. RRM clinicians correct deficiencies to optimal ranges, not just "normal" laboratory values.

For individuals with MTHFR variants, methylated folate forms are preferred over synthetic folic acid. Omega-3 fatty acids support healthy inflammation responses and hormone production. The guiding principle: supplements support the body's natural reproductive processes when specific deficiencies exist, but they cannot replace proper diagnosis and treatment of underlying conditions.

• CoQ10 supplementation improved oocyte quality markers in women over 35 and enhanced sperm concentration and motility (Bentov et al., 2014; Safarinejad, 2012)
• Vitamin D deficiency found in 67-85% of women with PCOS, with correction improving ovulation rates (Thomson et al., 2012)
• Myo-inositol restored ovulation in 70% of women with PCOS within 16 weeks (Costantino et al., 2009)
• Omega-3 supplementation improved sperm quality parameters in multiple studies (Safarinejad et al., 2010)

RRM supplement protocols target documented deficiencies through testing, using evidence-based nutrients to support natural reproductive function while addressing root causes of fertility challenges.

This information is educational and not a substitute for individualized medical care. Consult an RRM clinician or healthcare provider for guidance specific to your situation.