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Identification of two related pentapeptides from the brain with potent opiate agonist activity
Nature, 258(5536), 577-580
DOI 10.1038/258577a0 PMID 1207728
Abstract
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
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Cite this article
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975). Identification of two related pentapeptides from the brain with potent opiate agonist activity. *Nature*, *258*(5536), 577-580. https://doi.org/10.1038/258577a0
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975;258(5536):577-580. doi:10.1038/258577a0
Hughes, Joel, et al. "Identification of two related pentapeptides from the brain with potent opiate agonist activity." *Nature*, vol. 258, no. 5536, 1975, pp. 577-580.
Keywords
Amino Acid Sequence, Animals, Brain/metabolism, Brain Chemistry, Ligands/analysis, Muscle Contraction/drug Effects, Naloxone/pharmacology, Nerve Tissue Proteins/analysis/pharmacology, Oligopeptides/analysis/pharmacology, Opium/metabolism, Receptors, Drug, Swine, Ligands, Nerve Tissue Proteins, Oligopeptides, Receptors, Drug, Naloxone, Opium