Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Wang N, Chen Z, Yao Y, Sun C, Wei W, Sun L, Zhang H, Li F, Butcher D, Sun SR, Gong J, Jiang YC, Qi Y, Huang J, Nettelfield S, Liu R, Zheng X, Li C, Fu Y, Geng H, Zhao L, Sun H, Yang Y, Ge Y, Pazhouhandeh M, Barlow CK, Jeppe KJ, Yunis J, Zhu C, Wei Y, Liang X, Bridle K, Frazer DM, Tey SK, Li Y, Yang Z, Shu M, Liu Z, Crawford D, Yu D

doi:10.1038/s41586-026-10193-4

Nature, 2026

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Wang N, Chen Z, Yao Y, Sun C, Wei W, Sun L, Zhang H, Li F, Butcher D, Sun SR, Gong J, Jiang YC, Qi Y, Huang J, Nettelfield S, Liu R, Zheng X, Li C, Fu Y, Geng H, Zhao L, Sun H, Yang Y, Ge Y, Pazhouhandeh M, Barlow CK, Jeppe KJ, Yunis J, Zhu C, Wei Y, Liang X, Bridle K, Frazer DM, Tey SK, Li Y, Yang Z, Shu M, Liu Z, Crawford D, Yu D

DOI10.1038/s41586-026-10193-4 PMID41781622

Read at publisher

Abstract

No abstract available for this article.

Topics

General OB/GYN > Nutrition > Lipid Metabolism and Immunity Research Methodology > Basic Science > Immunometabolism

lipid metabolism T cell ferroptosis dietary effects, dietary fat T cell immunity ferroptosis, lipid metabolism adaptive immunity T cell function, ferroptosis immune regulation diet, T cell ferroptosis lipid peroxidation dietary intervention, nutritional immunology T cell lipid metabolism, dietary effects on T cell function ferroptosis pathway, iron dependent cell death T cells lipid metabolism, Wang Sun Nature ferroptosis immunity diet, metabolic regulation T cell antitumor immunity

PMID 41781622 41781622 DOI 10.1038/s41586-026-10193-4 10.1038/s41586-026-10193-4

Cite this article

Wang, N., Chen, Z., Yao, Y., Sun, C., Wei, W., Sun, L., Zhang, H., Li, F., Butcher, D., Sun, S. R., Gong, J., Jiang, Y. C., Qi, Y., Huang, J., Nettelfield, S., Liu, R., Zheng, X., Li, C., Fu, Y., . . . Yu, D. (2026). Lipid metabolism drives dietary effects on T cell ferroptosis and immunity. *Nature*. https://doi.org/10.1038/s41586-026-10193-4

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Abstract

Topics

Cite this article

Related articles

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

Origin of luteinizing hormone-releasing hormone neurons

Morphine and beta-endorphin influence the secretion of the endocrine pancreas

Identification of two related pentapeptides from the brain with potent opiate agonist activity